摘要
目的探讨拜阿斯匹林、阿托伐他汀合用预防脑梗再发的临床效果。方法将首发脑梗患者168例随机分成2组,治疗组86例给予拜阿斯匹林100～150mg晚服1次,阿托伐他汀10～20mg晚服1次;对照组82例给予拜阿斯匹林100～150mg晚服1次,降血脂用非他汀类药物;两组脑梗死病人基础治疗相同,并分别在入院时治疗后第3、6、12个月动态监测血液流变学变化,血脂水平变化;评估颈动脉斑块积分变化;计算1年内两组脑梗再发率。结果两组病人均完成12个月的随诊观察,治疗组脑梗再发率3.7%,明显低于对照组10.8%,P<0.01。两组血液流变学变化、血脂水平变化与入院时比较有显著差异性(P<0.05)组间比较无显著异性(P>0.05)。治疗组颈动脉斑块积分变化与入院时比较均(P<0.05)有显著差异性,对照组治疗前后比较无差异性(P>0.05);两组之间比较有显著差异性(P<0.05)。结论拜阿斯匹林联阿托伐他汀预防脑梗再发优于单用阿斯匹林。改善血液流变学,调脂效果理想。可减轻延缓,甚至逆转颈动脉粥样硬化的进展,抑制斑块形成,降低脑梗再发率。
Objective： To explore the clinical effect of the combination of baiaspirin and atorvastatin on prevention of the recurrence of cerebral infarction. Methods： 168 patients with first brain infarction were randomly divided into two groups. The treatment group （n=86） received the combined treatment of bayaspirin and atorvastatin, 82 cases of the control group were given baiaspirin and other non-statin cholesterol-lowering drugs. The basic treatments of two groups were same. The changes of hemorheology values, the contents of blood lipid and the scores of carotid artery plaque were monitored dynamically at the end of 3rd, 6th, 12th months after treatment. And the recurrence rate of cerebral infarction within one year was calculated. Results： The recurrence rate of the cerebral infarction in treatment group（4.6 %） was significantly lower than the control group （11 %） （P〈0.01）. In two groups, there were significant difference between pre and post treatment in the changes of hemorheology values, the contents of blood lipid and the scores of carotid artery plaque （P〈0.05）, but there were no significant difference between two groups （P〈0.05）. In the treatment group, there was significant differences between pre and post treatment in the change of the score of carotid artery plaque （P〈0.05）, but there was no difference in the control groups （P〉0.05）, there was significant difference between two groups （P〈0.05）.Conclusion： The curative effect of Bayaspirin combined with atorvastatin is superior to aspirin alone on prevention of recurrence of cerebral infarction.
出处
《井冈山大学学报（自然科学版）》
2010年第3期95-97,共3页
Journal of Jinggangshan University (Natural Science)
关键词
拜阿斯匹林
阿托伐他汀
脑梗再发预防
临床分析
baiaspirin
atorvastatin
prevention of recurrence of the cerebral infarction
clinical analysis
