摘要
部分患者无明显临床症状。故当从病机出发探讨非酒精性脂肪性肝病fnon—alcoholicfattyliverdisease，NAFLD）的中医病名，如“肝癖”．NAFLD的发病与饮食、劳逸及精神因素等有关，但目前对不同病因之间的区别缺乏深入研究．痰瘀互结、痹阻肝络是NAFLD的病机共性，但不同阶段之间的具体病机存在差异，目前对此研究不足．NAFLD的治疗有辨证论治、专法专药，以及辨病辨证相结合等，但均缺乏严谨有效的评价体系，对患者生存质量也不够重视．实验研究集中体现在证候及单味药物治疗机制的研究上，但存在造模方式未体现中医特色，以及中药安全性和中药复方机制研究不足的问题．
As some patients with nonalcoholic fatty liver disease （NAFLD） have no obvious clinical symptoms, we propose that NAFLD should be named ＂Ganpi＂ in Chinese medicine （CM） since it better reflects the pathogenesis of the disease. Although it is believed that the development of NAFLD is related to improper diet, irregular lifestyle habits and emotional disturbance, there is no thorough research on the differences among the syndromes resulting from these causes. The accumulation of phlegm and blood stasis in the liver collateral is the common pathogenesis of various types of NAFLD. At present, there are insufficient data concerning detailed pathological changes in different stages of NAFLD. The therapies for NAFLD include： treatment based on syndrome differentiation, specific recipes and drugs, and treatment based on the combination of disease differentiation and syndrome differentiation. However, the efficacy evaluation system is not rigorous and effective, and little importance is attached to the quality of life of NAFLD patients. Most experimental studies concentrate on syndrome and therapeutic mechanism of a single herb, and few studies focus on the safety of herbs and the mechanism of compound prescriptions.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第14期1442-1451,共10页
World Chinese Journal of Digestology
基金
国家“十一五”科技支撑计划基金资助项目,No.2007BAI208096
关键词
非酒精性脂肪性肝病
病因病机
临床研究
实验研究
述评
Nonalcoholic fatty liver disease
Etiology and pathogenesis
Clinical research
Experi-mental research
Review
