摘要
目的探讨腔内注射干扰素治疗晚期非小细胞肺癌患者恶性胸腔积液的疗效与胸水中Th1/Th2型细胞因子的关系。方法对晚期非小细胞肺癌合并恶性胸腔积液患者每周以干扰素500万单位行腔内注射,连续4周,评价其疗效。同时采用流式细胞术检测胸水中IL-2、IFN-γ、IL-4和IL-10水平,比较干扰素治疗有效组与无效组治疗前后各细胞因子的变化。结果干扰素治疗有效组IL-2和IFN-γ上升,IL-4和IL-10下降(P<0.05);无效组各细胞因子变化无统计学差异(P>0.05)。结论晚期非小细胞肺癌患者恶性胸水中Th1细胞因子优势化是影响其治疗效果的主要因素之一。
Objective To study the relationship between the efficacy of IFN treating malignant hydrothorax of non-small cell lung cancer and Th1/Th2 cytokines in malignant hydrothorax.Methods In stage ⅢA or Ⅳnon-small cell lung cancer patients with malignant hydrothorax with interferon 500 million units per week injected for four weeks,and the efficacy of IFN were evaluated.Using streaming cells,the levels of IL-2,IFN-g,IL-4 and IL-10 in malignant hydrothorax were determined.Of the patients treated with intrapleural injection of IFN,the changes of these cytokines before and after the treatment were compared between the responsive cases and the unresponsive cases.Results In the patients who had response to IFN,the levels of IL-2 and IFN-g were increasing after the treatment and IL-4 and IL-10 were decreasing before the treatment vs after the treatment,（P〈0.05）,while in those who had no response to IFN these cytokines had no significant difference before and after the treatment（P〉0.05）.Conclusion Th1 cytokines superiority in malignant hydrothorax may be one of the main elements of IFN for the treatment of malignant hydrothorax of non-small cell lung cancer.
出处
《临床肺科杂志》
2010年第7期978-980,共3页
Journal of Clinical Pulmonary Medicine
基金
云南省教育厅科学研究基金项目(编号:07Y10626)
