摘要
在酵母诱导的发热大鼠中，桂枝汤有效部位Ａ（Ｆｒ．Ａ）能降低隔区ＡＶＰ和下丘脑ＮＴ含量，对下丘脑ＡＶＰ含量无影响；在安痛定诱导的低体温大鼠中，Ｆｒ．Ａ能提升下丘脑、隔区ＡＶＰ含量和下丘脑ＮＴ含量。结果提示，Ｆｒ．Ａ对发热动物的解热作用与影响下丘脑ＮＴ和隔区ＡＶＰ的释放有关；抑制中枢ＡＶＰ和ＮＴ的释放或利用参予Ｆｒ．
Active fraction A(Fr.A),isolated from Guizhi decoction,might lower febrifacient temperature induced by y east in febrile rat with decreasing contents of arginine vasopressin (AVP) in ventral septal area(VSA) and neurotensin(NT) in hypothalamus.Fr.A did not influence the content of AVP in hypothalamus.In aminopyrine induced hypothermal rats,Fr.A could raise body temperature and contents of AVP in both hypothalamus and VSA and NT in hypothalamus.The results indicated that febrifugal effect of Fr.A was related with its promoting release of AVP in VSA and NT in hypothalamus,while its inhibiting release and/or action of AVP and NT in the thermoregulatory center was involved in mechanism of Fr. A ragulating hypothermia.
出处
《中国实验方剂学杂志》
CAS
1999年第1期33-36,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金
关键词
桂枝汤
体温调节
精氨酸加压素
神经降压素
active fraction A of Guizhi decoction,Dual directional thermoregulation,arginine vasopressin,neurotensin
