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逍遥丸对高架十字迷宫小鼠行为影响的实验研究 被引量:3

Experimental Research about the Effect of Xiaoyao Pill on Behavior of EPM Mice
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摘要 目的:通过小鼠高架十字迷宫实验,了解逍遥丸的抗焦虑作用。方法:连续给予逍遥丸7天后,进行高架十字迷宫实验。记录动物的OE、CE、OT、CT、HD和RE值等指标。结果:逍遥丸3个剂量均能提高高架十字迷宫小鼠的OE+CE、OE/(OE+CE)、OT/(OT+CT)值,降低RE、HE值,并且存在一定的量效关系,其中高剂量组的效果最好。结论:逍遥丸具有明显的抗焦虑作用。 Objective:To study the anti-anxiety effects of Xiaoyao pill on EPM mice by the EPM experiments.Methods :Xiaoyao pill was given to mice for seven days,and OE,CE,OT,CT,HD,RE were recorded.Result :Three doses of Xiaoyao pill all can increase the EPM mouse OE+CE,OE/(OE+CE),OT/(OT+CT),lower RE,HE value,and there is a certain degree of dose-effect relationship,in which high-dose group is the best.Conclusion :Xiaoyao pill has the effect of anti-anxiety.
出处 《辽宁中医药大学学报》 CAS 2010年第6期265-266,共2页 Journal of Liaoning University of Traditional Chinese Medicine
关键词 逍遥丸 高架十字迷宫 抗焦虑 Xiaoyao pill EPM anti-anxiety
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参考文献2

  • 1Lister RG. The use of a plus-maze to measure anxiety in the mice [ J ]. Psvchophaimacolony ( Bed ), 1987,92 (2) : 180.
  • 2File SE, WARDILL AG.Validity of head-dipping as a measure of exploration in a modified hole board[ J ]. Psychopharmaccologia, 1975,44( 1):53.

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