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1,2-二苯氧基乙烷的合成及工艺 被引量:3

Synthesis of 1,2-Diphenoxyethane and Optimized Process
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摘要 采用水相体系直接合成得到高纯度的1,2-二苯氧基乙烷,在优化工艺条件下,以1,2-二溴乙烷和苯酚为基本原料,KOH为碱,1,2-二苯氧基乙烷摩尔收率达75%,产品气相色谱纯度达99%,且完成了10 kg/批的扩大合成实验评价,效果稳定。最优合成工艺为:反应时间25 h,w(KOH)=50%的水溶液,n(KOH)∶n(苯酚)∶n(1,2-二溴乙烷)=3.0∶3.0∶1.0,反应温度60℃。在该条件下,产物中杂质的生成量较少。 1,2-Diphenoxyethane with high purity was successfully synthesized by 1,2-dibromoethane reacting with phenol in the aqueous KOH solution.Under the optimized reaction conditions,the molar yield of 1,2-diphenoxyethane exceeding 75% on the basis of 1,2-dibromoethane and GC purity exceeding 99% were achieved.This attractive result was confirmed by a series of scale-up test with 10 kg/batch size.The following optimized conditions were obtained: the optimized reaction time is 25 h,the concentration of base is w(KOH)=50%,and the molar ratio of the main reactants is n(KOH)∶n(phenol)∶n(1,2-dibromoethane)=3.0∶3.0∶1.0.The reaction temperature is 60 ℃.With the above optimized conditions,the impurity contained in the final product can be decreased to a limited level.
作者 曹育才 朱汕
机构地区 上海化工研究院
出处 《精细化工》 EI CAS CSCD 北大核心 2010年第5期512-515,共4页 Fine Chemicals
基金 上海市科委科技计划资助项目(04cg51005 065211021 09QB1401800)~~
关键词 1 2-二苯氧基乙烷 乙二醇二苯醚 对称双醚 1 2-diphenoxyethane diphenyl glycol ether symmetric diether
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参考文献14

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