摘要
目的观察脐血干细胞移植治疗失代偿期肝硬化患者的临床疗效。方法失代偿期肝硬化患者34例,其中乙型或丙型肝炎肝硬化22例,乙型肝炎与酒精性混合性肝硬化3例,酒精性肝硬化4例,胆汁性肝硬化4例,肝豆状核变性所致肝硬化1例;Child-Pugh分级:A级3例,B级21例,C级10例。所有患者术前均行肝功能及影像学等检查,无菌采取脐血并分离出干细胞,经肝动脉将干细胞悬液移植入肝脏,分别在移植后第1周、1个月、3个月、6个月复查肝功能,观察实验室指标、临床症状及不良反应情况。结果干细胞移植术后大部分患者症状明显改善;术后6个月ALT由均值56.9U/L降至46.3U/L,TBil由47.3μmol/L降至24.6μmol/L,Alb由30.9g/L上升至35.5g/L,PT由17.9s降至16.4s;术后复查B超仅1例患者腹水增多,15例腹水明显减少,9例腹水消失;34例患者未发现严重不良反应及并发症。结论脐血干细胞移植安全可行,可不同程度改善肝硬化患者临床症状、肝功能和凝血功能。
Objective To investigate the clinical therapeutic effect of umbilical blood stem cell transplantation in patients with decompensated cirrhosis.Methods Thirty-four patients of decompensated cirrhosis were included.Among them,twenty-two were viral hepatitis cirrhosis,three were hepatitis B and alcoholic cirrhosis,four alcoholic cirrhosis,four biliary cirrhosis and one cirrhosis with Wilson＇s disease.After isolation and purification,the umbilical blood stem cells were transplanted into the liver via hepatic artery.The biochemical index of ALT,TBil,Alb,PT and clinical symptoms were detected at different times after transplantation （1 week,1 month,3 months,6 months）.Results Most of the patients have significant improvement in symptoms after the stem cell transplantation;At six month after transplantation,the mean alanine aminotransferase level decreased from 56.9 U/L to 46.3 U/L,the mean total serum bilirubin decreased from 47.3 μmol/L to 24.6 μmol/L,the mean albumin level increased from 30.9 g/L to 35.5 g /L,the mean prothrombin time decreased from 17.9 s to 16.4 s.Under abdominal B ultrasonography,ascites only increased in one case,but decreased significantly in 15 cases and disappeared in 9 cases.No severe adverse effect and serious complication occurred.Conclusions Umbilical blood stem cell transplantation is feasible and safe,which can improve clinical symptoms,liver function and blood coagulation function in varying degrees.
出处
《肝脏》
2010年第2期81-83,共3页
Chinese Hepatology
关键词
脐血
干细胞移植
肝硬化
Uumbilical blood
Stem cell transplantation
Cirrhosis
