摘要
目的探讨骨代谢生化指标血Ⅰ型胶原交联氨基末端肽(NTx)和骨唾液酸蛋白(BSP)的检测对非小细胞肺癌骨转移的临床意义。方法临床确诊的非小细胞肺癌患者76例,初诊时分为骨转移组和无骨转移组,用ELISA法检测血清骨生化标记物血清NTx和BSP水平。随访6个月应用影像学检查对骨转移重新评估。结果骨转移组血清NTX和BSP水平显著高于无骨转移组,差异有统计学意义(P<0.01)。44例无骨转移癌患者中有12例在随访过程中新发生骨转移癌。新发骨转移癌组和初诊骨转移组NTx和BSP水平均显著高于无骨转移组,差异有统计学意义(P<0.05)。结论血清NTx和BSP是诊断非小细胞肺癌骨转移的重要参考指标,其水平的增高是预测骨转移发生的高危因素。
Objective To study the clinical significance of assaying the serum pyridinoline cross-linked N-telopeptides of type I collagen（NTx） and bone sialoprotein（BSP）to diagnosis of bone metastases for patients with non-small-cell lung cancer.Methods A total of 76 patients with non-small-cell lung cancer were enrolled and divided into 2 groups： bone metastasis group（n=32） and non-bone metastasis group（n=44）.The levels of serum NTx and serum BSP were measured by ELISA.The bone metastasis was assessed again by imaging examination after 6-month follow-up.Results The levels of NTx and BSP in patients with bone metastasis were significantly higher than those in the patients without bone metastasis（P0.01）.Among the 44 patients without bone metastasis 12 were found to have new metastasis during the follow up.The levels of NTx and BSP in patients with both new and old bone metastasis were significantly higher than those in the patients without bone metastasis（P0.05）.Conclusion The serum NTx and BSP are important biomarkers for diagnosis of bone metastasis,and the increase of their levels can be regarded as risk factors for bone metastasis.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第16期1771-1772,共2页
Chinese General Practice
