摘要
目的探讨慢性阻塞性肺疾病(COPD)呼吸衰竭患者血清甲状腺激素的变化及其临床意义。方法用电化学发光免疫分析法测定50例COPD呼吸衰竭患者急性发作期、缓解期及50名正常对照者的血清甲状腺激素总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)水平。结果呼吸衰竭组急性发作期患者血清T3、T4、FT3水平均显著低于缓解期患者(P<0.05)及对照组(P<0.01);呼吸衰竭死亡者血清T3、T4、FT3水平均显著低于缓解期患者(P<0.001)。结论 COPD呼吸衰竭急性发作期患者血清T3、T4、FT3明显低于正常人,缺氧是导致甲状腺激素水平变化的重要因素之一,监测血清甲状腺激素的变化有助于判断COPD患者病情危重程度和预测预后。
Objective To investigate the alterations of serum thyroid hormone levels in patients with respiratory failure of chronic obstructive pulmonary disease（COPD） and its clinical significance. Methods Serum thyroid hormone levels were measured by chemiluminescence immunoassay in 50 COPD patients with respiratory failure in the acute exacerbation phase and in the stable phase,and in 50 healthy subjects as controls. Results The serum TT3,TT4 and FT3 levels were signifi cantly lower in acute exacerbation phase of COPD patients than those in stable phase of COPD（P〈0.05） and in controls（P〈0.01）;The serum TT3,TT4 and FT3 levels were significantly lower in the fatal cases of COPD with respiratory failure,than those in survival cases（P〈0.01） . Conclusion Serum levels of thyroid hormone reduced in patients with COPD at their acute stage,signifi cantly lower than those in control group. Anoxia was one of important factors causing changes in serum levels of thyroid hormones. Monitoring of serum levels of thyroid hormones may be useful in predicting their severity and outcome for patients with COPD.
出处
《中国医药指南》
2010年第17期15-16,24,共3页
Guide of China Medicine
关键词
慢性阻塞性肺疾病
呼吸衰竭
甲状腺激素
Chronic obstructive pulmonary disease
Respiratory failure
Thyroid hormone
