摘要
目的探讨表皮生长因子受体（ＥＧＦＲ）在结直肠癌中的表达情况及其与病理特征和预后的关系。方法采用免疫组化ＳＰ法对有随访资料的５５例结直肠癌标本进行ＥＧＦＲ检测，结合图像分析观察判定结果。结果结直肠癌ＥＧＦＲ表达的阳性率为６９．０９％（３８／５５），ＥＧＦＲ的表达与肿瘤的浸润深度、淋巴结转移、Ｄｕｋｅ＇ｓ分期和生存期有关（Ｐ均＜０．０５），而与分化程度无关（Ｐ＞０．０５）。结论ＥＧＦＲ在结直肠癌的扩散和转移过程中可能产生一定的作用。
Objective\ To study the expression of epidermal growth factor receptor(EGFR) in colorectal carcinomas, and its clincal and pathological significance.\ Methods\ EGFR was determined immunohistochemically in 55 specimens of colorectal carcinomas which had been followed up regularly. \ The results were observed and judged through image analysis.\ Results The positive rate of EGFR in colorectal carcinomas was 69.09%(38/55). \ The expression of EGFR was concerned with infiltrative depth,lymphatic metastasis、Duke's stage and survival period of tumour(P<0.05 respectively),but was irrelative to differential degrees(P>0.05).\ Conclusion\ EGFR might play a definite role in the process of diffusion and metastasis of colorectal carcinomas, and be used as an important index for the assessment of prognosis.
出处
《福建医科大学学报》
1999年第1期31-34,共4页
Journal of Fujian Medical University
基金
福建省卫生厅科研基金
关键词
结肠直肠癌
病理
表皮生长因子
受体
epidermal growth factor receptor
colorectal carcinomas
immunohistochemistry
