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1-[N(2′-脱氧胞基)]-2-[N-(2′-脱氧鸟基)]乙烷的合成及其在DNA股间交联检测中的应用 被引量：1

Synthesis of 1-[N-(2'-deoxycytidyl)]-2-[N-(2'-deoxyguanosyl)] ethane and Its Application in the Detection of DNA Interstrand Crosslink
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摘要 以2′-脱氧鸟苷,2′-脱氧胞苷,2-氟乙醇等为原料合成了1-[N-(2′-脱氧胞基)]-2-[N-(2′-脱氧鸟基)]乙烷(dG-dC),其结构经1HNMR,IR和MS表征。以dG-dC为标准品,用HPLC-MS对1,3-双(2-氯乙基)-1-亚硝基脲导致DNA股间交联的损伤产物进行了定性分析。 1-[N-（2＇-deoxycytidyl）]-2-[N-（2＇-deoxyguanosyl）]ethane（dG-dC）was synthesized from 2＇-deoxyguanosine,2＇-deoxycytidine and 2-fluoroethanol.The structure was characterized by 1H NMR,IR and MS.Using dG-dC as a standard,the DNA interstrand crosslink induced by 1,3-bis-（2-chloroethyl）-1-nitrosourea（BCNU）was qualitatively analyzed by HPLC-MS.
作者 白宝清 赵丽娇 宋秀庆 钟儒刚
机构地区 北京工业大学生命科学与生物工程学院
出处 《合成化学》 CAS CSCD 北大核心 2010年第3期280-284,共5页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20907002) 北京市自然科学基金资助项目(8072006) 北京市优秀人才培养资助项目(20081A0501500179)
关键词 2′-脱氧鸟苷 2′-脱氧胞苷 合成 DNA股间交联 2＇-deoxyguanosine 2＇-deoxycytidine synthesis DNA interstrand crosslink
分类号 O626 [理学—有机化学] O657 [理学—分析化学]
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同被引文献23

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合成化学
2010年 第3期

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