摘要
将48只大鼠随机分成对照组和5个实验组,每组8只。实验组1~5组每只大鼠分别按体重4、8、13、16、20g/kg一次性灌胃47.5%酒精,对照组每只大鼠按体重20g/kg一次性灌胃生理盐水,灌胃后24h取肝组织进行病检。结果显示实验组各组炎细胞浸润、水变性均为100%,实验组3~5组脂肪变性、点状/片状坏死均为100%,而对照组未见异常病变,表明47.5%酒精摄入量在13g/kg以上可造成较严重的急性肝损伤。
The pathological change of acute liver injury in rats by the alcohol with different dose was investigated.48 rats were randomly divided into the five experimental groups（eight rats/each group） and the control group（eight rats）.The experimental groups were given the alcohol（47.5% v/v） at the dose of 4,8,13,16 and 20 g/kg body weight by gavages,and the control group was given the physiological saline.These rats were killed after 24h.Their hepatic tissues were examined by light microscope.The results indicated that inflammatory cell infiltration and the hydropic degeneration in hepatic tissues in all experimental groups were all 100%.The fatty degeneration and spotty necrosis/patchy necrosis in hepatic tissues were all 100% when the alcohol dose was 13g/kg and more.Abnormality was not found in the control group.We concluded that the serious acute liver injury of rat was arisen by the alcohol（47.5% v/v） with the dose of 13 g/kg and more.
出处
《孝感学院学报》
2010年第3期12-14,共3页
JOURNAL OF XIAOGAN UNIVERSITY
基金
湖北省教育厅科学研究重大项目(Z200626001)
孝感学院科研项目Z2008018)
关键词
酒精
急性肝损伤
病理变化
alcohol
acute liver injury
pathological change
