摘要
目的筛选快速、经济、成石效果好的大鼠肾草酸钙结石模型。方法采用国内常用的3种大鼠肾草酸钙结石造模方法及本次改良的造模法共4种方法诱导大鼠肾草酸钙结石模型,比较大鼠血钙、尿钙、血肌酐,观察肾草酸钙结晶形成情况,综合评价4种造模方法。结果改良组[1%乙二醇+2%氯化铵+10%葡萄糖酸钙(14d)]与B组[1%乙二醇+2%氯化铵(28d)]肾草酸钙结晶较其他各组明显;改良组大鼠血肌酐明显高于其他各组。结论改良组成石效果好,成石时间短,经济,但肾功能损害较大。
Objective： To select a fast, economical and satisfied model of renal calcium oxalate calculus in rats. Methods： 4 methods, containing 3 common methods and l modified method, were used to reduce renal calcium oxalate calculus rat models. These indices were compared including the blood calcium, the urinary calcium, the serum creatinine and the calcium oxalate crystallization. Results： Calcium oxalate crystallization conditions in the modified group （1% ethylene glycol plus 2% ammonia chloride plus 10% calcium gluconate for 14 days） and the group B （1% ethylene glycol plus 2% ammonia chloride for 28 days） were more remarkable than those in other groups. The serum creatinine was higher obviously than that of other groups. Conclusion： The modified induction is a fast, economic and good calcium oxalate crystallized method. However, the damage of the renal function in the modified method is more serious than other ways.
出处
《中国中医急症》
2010年第6期1004-1006,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
国家中医药管理局科学技术研究专项(No.04-05ZP47)
关键词
泌尿系结石
草酸钙
大鼠
动物模型
Urinary calculi
Calcium oxalate
Rats
Animal model
