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^(18)F-FDG PET/CT对非小细胞肺癌治疗后纵隔淋巴结转移再分期的价值

Value of ^(18)F-FDG PET/CT for restaging metastasis of mediastinal lymph nodes in patients with non-small cell lung cancer
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摘要 目的应用18F-FDGPET/CT为手术或放化疗后非小细胞肺癌(NSCLC)患者进行再分期,以评价18F-FDGPET/CT在诊断纵隔淋巴结转移的价值。方法本组受检者51例(男41例,女10例),年龄34-90岁(平均61.86±12.81岁)。鳞癌29例,腺癌20例,腺鳞癌2例。根据文献中接收器工作特性分析确定良恶性结节阈值截点SUV值>3.5为阳性淋巴结。结果 51例患者中45例检出纵隔淋巴结,SUV值>3.5的阳性淋巴结共有63%(79/125),SUV值>3.5且小于1cm结节35%(28/79),SUV值>3.5且大于1cm结节65%(51/79)。肺腺癌20例中阳性淋巴结58%(46/79),鳞癌29例中阳性淋巴结41%(32/79),腺鳞癌2例中阳性淋巴结1%(1/79)。肺腺癌和鳞癌患者小于1cm和大于1cm的阳性淋巴结数量的差异有统计学意义(χ2=18.25,P<0.05)。结论 18F-FDGPET/CT对NSCLC治疗后纵隔淋巴结转移的再分期有较大价值。 Objective To evaluate the value of 18 fluorodeoxyglucose(FDG) positron emission tomography and computed tomography(PET/CT) for restaging metastasis of mediastinal lymph nodes in patients with non-small cell lung cancer(NSCLC) after treatment. Methods Of the 51 NSCLC patients(41 men and 10 women) at a mean age of 61 years(range 34-90 years) included in this study, 29 had squamous carcinoma, 20 had adenocarcinoma, and 2 had adenosquamous carcinoma. If the SUV threshold cutoff was 〉3.5 according to prior receiver operating characteristic analysis, the lymph nodes were defined as positive. Results Mediastinal lymph nodes were detected in 45 of the 51 patients. The SUV value was 〉3.5 in 63%(79/125) lymph nodes, in 35%(28/79) lymph nodes less than lcm in diameter, and in 65%(51/79) lymph nodes greater than lcm in diameter, respectively. The positive rate of lymph nodes was 58%(46/79), 41%(32/79), and 1%(1/79)in 20 patients with lung adenocarcinoma, in 29 patients with squamous carcinoma, and in 2 patients with adenosquamous carcinoma, respectively. No difference was found in the number of lymph nodes less or greater than lcm in diameter between patients with lung adenocarcinoma and those with squamous carcinoma( x2=18.25, P〈0.05). Conclusion 18F-FDG PET/CT has a high predictive value for restaging metastasis of mediastinal lymph nodes in NSCL patients.
出处 《军医进修学院学报》 CAS 2010年第7期650-652,共3页 Academic Journal of Pla Postgraduate Medical School
关键词 非小细胞肺 18F-FDG PET/CT 肿瘤分期 淋巴结 Carcinoma, Non-Small-Cell Lung 18F-FDG PET/CT Neoplasm Staging Lymph Node
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  • 1Graeter TP, Helluig D, Hoffmann K, et al. Mediastinal lymph node staging in suspected lung cancer : comparison of positron emission tomography with F-18-fluorodeoxyglucose and mediastinoscopy [ J ]. Ann Thorac Surg, 2003, 75 ( 1 ) : 231-235.
  • 2Cerfolio RJ, Bryant AS, Ojha B, et al. Restaging patients with N2 ( stage Ⅲa ) non-small cell lung cancer after neoadjuvant chemoradiotherapy : a prospective study [ J ] . J Thorac Cardiovasc Surg, 2006, 131 (6) : 1229-1235.
  • 3Dooms C, Vansteenkiste J. Positron emission tomography in nonsmall cell lung cancer [J] .Curr Opin Pulmned, 2007, 13 (4): 256-260.
  • 4Shim SS, Lee KS, Kim BT, et al. Accuracy of integrated PET/CT using fluorodeoxyglucose for the preoperative staging of non-small cell lung cancer : a prospective comparison with standalone CT [ J ] . Radiology, 2005, 236:1011-1019.
  • 5Lee EJ, Choi JY, Choi Y, et al. hnprovement in the differentiation of malignant nodes from benign nodes preoperatively in nonsmall cell lung cancer ( NSCLC ) using FDG PET/CT [ J ] . J Nucl Med, 2004, 45 : 374.
  • 6韩子阳,林若柏.PET/CT在肺癌临床分期中的应用价值[J].医学综述,2008,14(2):197-199. 被引量:1
  • 7Gupta NC, Graeber GM, Bishop HA, et al. Comparative efficacy of positron emmission tomography with fluorodeoxyglucose in evaluation of small(<1cm), intermediate(1 to 3cm), and large(>3cm) lymph node lesions [ J ]. Chest, 2000, 117 ( 3 ) : 773-778.
  • 8Gould MK, Kuschner WG, Rydzak CE, et al. Test performance of positron emission tomography and computed tomography for mediastinal staging in patients with non-small-cell lung cancer : a meta-analysis [ J ] . Ann Intern Med, 2003, 139 : 879-892.
  • 9Toloza EM, Harpole L, McCrory DC. Noninvasive staging of non- small cell lung cancer : a review of the current evidence [ J ] . Chest, 2003, 123 : 137S-146S.
  • 10王伦青,张哲,尹志伊,何宝亮,唐国健.原发性肺癌淋巴结清除临床价值的探讨[J].中华肿瘤防治杂志,2008,15(18):1408-1410. 被引量:7

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