摘要
目的 探讨艾滋病病毒（HIV）重叠乙型肝炎病毒（HBV）和/或丙型肝炎病毒（HCV）感染肝功能受损情况.方法 检测134例住院HIV阳性患者HBV、HCV感染血清标志物,分为HIV＋HCV、HIV＋HBV、HIV＋HCV＋HBV重叠感染三组,单纯性HIV感染作为对照组,对四组患者的肝功能指标进行回顾性分析.结果 HIV合并HCV感染最常见达74%.对照组ALT值中位数为26U/L（16.25～37）,重叠感染组HIV＋HBV、HIV＋HCV、HIV＋HBV＋HCV的ALT值中位数分别为77（23～96）、43（23～75.5）、54（33.5～108）U/L,对照组与重叠感染组差异均有统计学意义（均P〈0.05）.PT值HIV＋HBV＋HCV组中位数为14.6 s（12.9～15.2）,明显高于其他三组（P〈0.05）.结论HIV重叠感染以合并HCV最高,重叠感染会加重肝功能损害,以同时重叠HCV、HBV感染组为明显.
Objective To investigate the damage of liver function in the AIDS/HIV patients with overlapping infection by hepatitis B virus （HBV） and hepatitis C virus （HCV）.Methods 134 hospitalized cases with HIV-positive were tested for HBV and HCV infection by detecting serum markers.According to the testing results,the patients were divided into four groups including HIV ＋ HCV group,HIV ＋ HBV group ,HIV ＋ HCV ＋ HBV group,single HIV infected group as a control.Retrospective analysis was conducted on liver function among these four groups of patients.Results The most common type was HIV ＋ HCV coinfection accounting for 74%.The median value of ALT in the control group was 26 U/L （16.25～37） ,while in the HIV ＋ HBV,HIV ＋ HCV,HIV ＋ HBV ＋ HCV groups it was 77（23～96） ,43（23～75.5） ,54（33.5～108） U/L,respectively.The control group was significantly different to overlapping infection groups （P〈0.05）.The median value of prothrombin time （PT） in HIV ＋ HBV ＋ HCV group is 14.6s（ 12.9～15.2）,significantly higher than the other three groups （P〈0.05）.Conclusion HCV overlapping infection was most frequent in HIV patients.liver function damage could be worsen in such patients especially in those with HBV and HCV positive simultaneously.
出处
《中国基层医药》
CAS
2010年第11期1472-1473,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
艾滋病病毒
肝炎病毒
感染
肝功能
AIDS virus,hepatitis virus
Infection
Liver function.
