摘要
目的:观察健脾化痰祛瘀方结合阿托伐他汀钙片治疗痰浊壅盛型高脂血症的临床疗效。方法:采用前瞻性研究方法,将80例高脂血症(痰浊壅盛型)患者分为治疗组(中药+阿托伐他汀钙片)与对照组(阿托伐他汀钙片)各40例。2组患者均常规晚餐时服用阿托伐他汀钙片10mg,qd;治疗组加服健脾化痰祛瘀方。疗程均为8周。观察血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的变化。结果:治疗组总有效率(92.5%)优于对照组(85.0%);2组TC、TG、LDL-C、HDL-C改善及头昏眩晕、身重困倦、胸闷心悸、腹胀纳呆等积分比较,治疗组症状改善均明显优于对照组(P<0.05);治疗过程中2组均未见明显不良反应。结论:中药联合阿托伐他汀钙片治疗痰浊壅盛型高脂血症优于单纯用阿托伐他汀钙片治疗,且2组安全性相当。
OBJECTIVE：To observe the clinical efficacy of strengthening spleen,reducing phlegm and stasis-dispelling recipe combined with atorvastatin calcium tablet for hyperlipidemia of phlegm-turbidity accumualtion.METHODS：In prospective study,80 patients with hyperlipidemia of phlegm-turbidity accumulation received traditional Chinese medicine combine with atorvastatin calcium tablet（therapy group） or atorvastatin calcium tablet alone（control group） with each group of 40 cases.Both groups were given oral dose of atorvastatin calcium tablet 10 mg before supper for 8 weeks.Therapy group were additionally given strengthening spleen,reducing phlegm and stasis-dispelling recipe.The levels of serum,TC,TG,HDL-C,LDL-C were observed.RESULTS：Total response rate of therapy group was 92.5%,which was better than control group of 85%.The improvements of TC,TG,LDL-C and HDL-C in therapy group were superior to control group.The improvement of clinical symptom in therapy group was better than control group according to the score of dizziness,sleepiness,chest tightness and palpitation,abdominal distention.Adverse drug reaction had not observed in both groups.CONCLUSION：Traditional Chinese medicine combine with atorvastatin calcium tablet has better effect than atorvastatin calcium tablet alone.2 groups show similar safety of drug use.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第24期2240-2241,共2页
China Pharmacy
关键词
痰浊壅盛
高脂血症
中西医结合
健脾化痰祛瘀法
阿托伐他汀钙片
Phlegm-turbidity accumulation
Hyperlipidemia
Integrated Chinese and western medicine
Strengthening spleen
reducing phlegm and stasis-dispelling recipe
Atorvastatin calcium tablet
