摘要
目的:研究瘤体内植入125Ⅰ粒子治疗兔VX2肝移植癌的疗效及其病理变化,探讨125Ⅰ粒子组织间植入治疗肝癌的可行性。方法:建立荷瘤兔肝移植癌动物模型。对照组(A组)植入空白剂量(0mCi)125Ⅰ粒子,B组植入1.0mCi125Ⅰ粒子,C组植入0.7mCi125Ⅰ粒子,D组植入0.4mCi125Ⅰ粒子。观察植入前后各组肿瘤体积并计算抑瘤率,切除肿瘤组织进行常规病理检查。结果:各治疗组肿瘤大小在治疗前后比较具有显著差异(P<0.01),均小于同期对照组(P<0.01)。在不同观察时期抑瘤率差别均有统计学意义(P<0.05),治疗1周后抑瘤率变化显著;各个组间抑瘤率差异在治疗后2周最为明显(P<0.01),以后减小,但均高于D组(P<0.01)。病理切片显示靠近125Ⅰ粒子处肿瘤细胞坏死,但远离粒子处仍可见存活肿瘤细胞。1.0mCi粒子对正常肝组织损伤较大。结论:125Ⅰ粒子组织间植入治疗肝癌有效,单个粒子活度以0.7mCi左右较为适宜。
Objective：To investigate the efficacy and pathological changes of rabbits VX2 liver tumor treated with 125I seeds interstitial brachytherapy. Methods： The New Zealand rabbits of VX2 liver transplantation for hepatoeellular carcinoma were randomly divided into 4 groups. Group A was the control group ; group B was implanted with 1.0mCi 125I seeds;group C was implanted with 0.7mCi seeds;group D was implanted with 0.4mCi seeds. The tumor volume was observed in order to calculate tumor inhibitory rate. The tumor histopathological examinations were performed. Results： The tumor size had conspicuous shrunk and the tumor inhibitory rate increased in groups B - D. The significant difference was found between prior -treatment and post -treatment in every group at different time （P 〈 0.05 ）. The tumor inhibitory rate had a predominant change in two weeks after treatment（ P 〈 0.01 ） , and the rate decreased after two weeks, but all rates of treatment groups were higher than the rate of group A. Pathological exami- nations showed the tumor cell necrosis near the 225I seeds, however, the survival of tumor cells still could be seen far away from the seeds. The injury happened in normal liver tissue when used in 1.0mCi 125I seed was more serious than that in 0.7 mCi and 0.4 mCi seed. Conclusion： It is effective of 125 1 radioactive seeds brachytherapy for liver cancer and it is appropriate to use a single seed activity of 0.7mCi around.
出处
《现代肿瘤医学》
CAS
2010年第6期1054-1056,共3页
Journal of Modern Oncology
基金
江苏省医学重点学科开放课题资助(编号:KF200916)
