摘要
目的:观察盐酸羟考酮控释片(奥施康定)治疗中重度肺癌疼痛的疗效,不良反应及患者生活质量改善情况,同时观察不同心理状态对疼痛程度和镇痛疗效的影响。方法:应用盐酸羟考酮控释片治疗76例中重度肺癌疼痛患者,盐酸羟考酮控释片起始剂量5mg/12h或10mg/12h,根据疼痛缓解程度调整剂量,直至达到满意镇痛效果,对其镇痛疗效,不良反应进行观察和评估。采用生活质量量表EORTCQLQ一C30(V3.0)中文版对肺癌疼痛患者镇痛治疗前后的生活质量进行评估。观察不同心理状态对疼痛强度和镇痛效果的影响。结果:入组的76例患者中,有74例可评价疗效和安全性,其中67例(90.5%)达到满意的疼痛缓解,平均达有效维持剂量时间为2.4天。消极悲观者疼痛程度重、镇痛效果差,积极乐观者疼痛程度轻、镇痛效果佳。主要不良反应为便秘、恶心呕吐、头晕、排尿困难、嗜睡。在疼痛缓解的同时,肺癌疼痛患者的生活质量得到了明显改善。结论:心理状态与疼痛程度和镇痛疗效密切相关;盐酸羟考酮控释片治疗中重度肺癌疼痛安全有效,能明显改善肺癌疼痛患者的生活质量。
Objective：To evaluate the efficacy, adverse reactions and the improvement of quality of life （QOL） of oxycodone hydrochloride controlled - release tablets （ MS Contin Austria） in patients with lung cancer pain, and to observe the effects of different psychological effect on pain intensity and analgesic effects. Methods： Oxycodone hydro- chloride controlled - release tablet was used in treatment of 76 lung cancer cases with moderate and severe pain, oxycodone hydrochloride ontrolled -release tablets starting dose was 5mg/12h or 10mg/12h, adjust the dose according to the degree of pain relief, until a satisfactory analgesic effect. QOL was assessed in 66 lung cancer patients, using EORTC QLQ - c30. Results： Of 76 patients enrolled,74 patients were evaluable of which 67 cases （90.5%） a- chieved satisfactory pain relief. The main adverse reactions were constipation, nausea, vomiting, dizziness, drowsiness, difficulty urinating, the quality of life was improved significantly. Conclusion：Psychological status , degree of pain and analgesic efficacy is closely related; oxycodone hydrochloride controlled - release tablet treatment for moderate or severe cancer pain is safe and effective;it markedly improves the quality of life in patients with lung cancer.
出处
《现代肿瘤医学》
CAS
2010年第6期1120-1122,共3页
Journal of Modern Oncology
关键词
羟考酮控释片
肺癌
疼痛治疗
生活质量
oxycodone controlled- release tablets
lung cancer
treatment of pain
quality of life
