摘要
目的 观察主动免疫治疗刺激机体产生的免疫性抗体对新生儿溶血病发生率的影响.方法 采用皮下注射丈夫淋巴细胞方法对治疗组患者进行免疫治疗;观察分析免疫治疗及孕产妇血清HLA抗体对新生儿溶血病（hemolytic disease of newborn,HDN）患儿溶血程度的影响.结果 对照组孕妇HLA抗体阳性率为21.2%,治疗组为53.3%;对照组新生儿发生重症新生儿溶血病11例（33.3%）;治疗组1例（3.3%）.二者比较,差异有显著性（P〈0.01）.结论 主动免疫治疗能够刺激机体产生HLA抗体,可有效降低血型不合所致重症新生儿溶血病的发病概率.HLA抗体参与了HDN的发生、发展及转归.孕期动态监测HLA抗体对发生新生儿溶血病的轻重程度有预报作用.
Objective To observe the influence of active immunotherapy on newborn hemolytic disease （ HDN ）. Methods The marital lymphocytes was injected subcutaneously to treat the patients with HDN. The influence of active immunotherapy and maternal serum HLA antibodies on children with HDN was observed. Results HLA anti- body positive rate was 21.2% in control group and 53.3% in treatment group. There were 11 newborn suffered from severe hemolytic disease in control group, and only 1 in treatment group （ P 〈 0.01 ）. Conclusions Active immunotherapy could stimulate the body to produce HLA antibodies and effectively reduce the occurrence of severe HDN. HLA antibody may be involved in the occurrence and development of HDN. Dynamic monitoring the level of HLA antibody could predict the severity of HDN in pregnancy.
出处
《潍坊医学院学报》
2010年第2期89-90,共2页
Acta Academiae Medicinae Weifang
关键词
免疫性抗体
新生儿溶血病
主动免疫治疗
Immune antibody
Newborn hemolytic disease
Active immunotherapy
