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来曲唑促排卵治疗不孕症患者22例疗效观察 被引量:1

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摘要 目的探讨来曲唑用于对克罗米酚反应不良无排卵性不孕妇女的促排卵效果。方法选择2005年3月至2007年3月就诊于我所的克罗米酚反应不良患者45例,随机分为两组,来曲唑组(实验组)22例在月经周期第3-7天口服来曲唑(LE)2.5mg/d,尿促性素组(对照组)23例在月经周期第3天开始采用低剂量递增法肌注尿促性素(HMG),超声监测卵泡发育,当至少有1个卵泡≥18mm时,22例来曲唑组均肌注绒毛膜促性腺激素(HCG)5000-10000IU诱发排卵,23例尿促性素组中16例肌注绒毛膜促性腺激素(HCG)5000-10000IU诱发排卵。结果来曲唑组的子宫内膜厚度与尿促性素组相似,来曲唑组单卵泡发生率明显高于尿促性素组,其平均成熟卵泡数显著低于尿促性素组,来曲唑组与尿促性素组卵泡未破裂黄素化(LUF)发生例数分别为3例、4例,尿促性素组有1例发生卵巢过度刺激综合征。结论来曲唑用于对克罗米酚反应不良的不孕妇女具有良好的排卵率,且单卵泡发生率高于尿促性素。
作者 窦亚芳
出处 《海南医学》 CAS 2010年第12期83-84,共2页 Hainan Medical Journal
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