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瞬时受体电位阳离子通道蛋白6与肾脏疾病 被引量：2

TRPC6 and kidney diseases
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摘要 瞬时受体电位阳离子通道蛋白6(transient receptor potential cation channel 6,TRPC6)是一个非选择性阳离子通道,定位于足细胞膜,为6次跨膜蛋白。TRPC6与裂孔隔膜分子nephrin以及podocin间存在相互作用,其共同组成裂孔隔膜复合体,突变TRPC6干扰了该复合体的功能,导致足细胞不能维持正常的生物学功能。研究发现TRPC6基因突变与遗传性和非遗传性肾脏疾病发病密切相关,突变的TRPC6可能通过使足细胞动力学发生改变以及足细胞数量减少而引起肾脏疾病。阻断TRPC6通道可能是一种治疗蛋白尿性肾脏疾病的有效方法 ,将给肾病患者带来长期的临床效应。 Transient receptor potential cation channel 6（TRPC6） is a nonselective cation channel,located in the podocyte cell membrane and contains six membrane-spanning domains.TRPC6 is associated with slit diaphragm proteins-nephrin and podocin,the three proteins composing the slit diaphragm complex.Mutant TRPC6 may affect the function of this complex,leading to abnormalities in podocyte foot processes.Research suggested that mutant TRPC6 closely correlated with the mechanism of hereditary and non-hereditary nephropathies,possibly by altering podocyte dynamics and decreasing podocyte number.Blocking TRPC6 channels might be of therapeutic effect in treating kidney disease with proteinuria,and it may translate into long-lasting clinical benefits in patients with nephropathy.
作者 张瑶 于力
机构地区 广州医学院附属广州市第一人民医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2010年第6期594-597,共4页 Journal of Clinical Pediatrics
基金 广州市科技攻关计划项目(No.2006Z3E0231)
关键词 瞬时受体电位阳离子通道蛋白6 肾脏疾病 蛋白尿 transient receptor potential cation channel 6 kidney disease proteinuria
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献25

  • 1Moller CC,Wei C,Altintas MM,et al.Induction of TRPC6 channel in acquired forms of proteinuric kidney disease[J].J Am Soc Nephrol,2007,18(20):29-36.
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二级参考文献21

  • 1范青锋,丁洁.肾小球足细胞系的研究进展[J].实用儿科临床杂志,2005,20(1):71-72. 被引量：5
  • 2段波,徐天乐.TRP通道与信号转导[J].生物物理学报,2005,21(4):245-260. 被引量：20
  • 3潘晓霞,陈楠,周伟,王朝晖,张文,王伟铭,陈晓农,巫永睿,陆颖.原发性局灶节段性肾小球硬化患者CD2AP基因突变的研究[J].中华肾脏病杂志,2006,22(1):13-18. 被引量：24
  • 4Winn MP, Conlon PJ, Lynn KL, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis [ J ]. Science, 2005,308 ( 5729 ) : 1801 - 1804.
  • 5Reiser J, Polu KR, Moller CC, et al. TRPC6 is a glomerular slit diaphragm- associated channel required for normal renal function[J]. Nat Genet ,2005 ,37 ( 7 ) :739 - 744.
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共引文献12

同被引文献82

  • 1王海燕.肾脏病学.3版.北京:人民卫生出版社,2008.
  • 2Kambiz ZN, Eddy AA, Glassock RJ, et al. Why is proteinuria an omnious biomarker of progressive kidney disease? Kidney lnt, 2004, 66 suppl 92 :S76-S89.
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  • 10Woudenberg-Vrenken TE, Bindels RJM, Hoenderop JGJ. The role of transient receptor potential channels in kidney disease. Nat Rcv Nephrol.2009.5:441-449.

引证文献2

二级引证文献9

临床儿科杂志
2010年 第6期

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