摘要
目的探讨慢性肝炎患者血清中结缔组织生长因子(CTGF)、血小板衍生生长因子-BB(PDGF-BB)以及可溶性细胞黏附分子-1(sICAM-1)在肝纤维化诊断中的临床价值。方法用ELISA法检测192例慢性肝炎患者血清中CTGF、PDGF-BB以及sICAM-1,并与肝穿刺病理检查结果进行相关性分析;用ROC曲线评估这些指标在肝纤维化诊断中的价值。结果血清CTGF、PDGF-BB、sICAM-1均与肝纤维化分期呈正相关,ROC曲线下面积(AUC)分别为0.817、0.765、0.733;联合CTGF、PDGF-BB以及sICAM-1可以明显提高诊断的准确性。结论血清CTGF、PDGF-BB、sICAM-1是预测肝纤维化分期较好的标记物,在肝纤维化程度评价中有较高的应用价值。
Objective To assess the clinical value of connective growth tissue factor （CTGF）,platelet-derived growth factor-BB （PDGF-BB）,and soluble intercellular adhesion molecule-1 （sICAM-1）in the sera of patients with liver fibrosis.Methods Serum CTGF,PDGF-BB and sICAM-1 in 192 patients with chronic hepatitis were determined by using enzyme linked immunosorbent assay （ELISA）.Spearman correlation statistical analysis was used to evaluate the relationship between the levels of CTGF,PDGF-BB,sICAM-1 and the stage of fibrosis.The diagnostic performance of CTGF,PDGF-BB,and sICAM-1 was assessed by the area under receiver characteristic curves （ROC）.Results The levels of serum CTGF,PDGF-BB,and sICAM-1 were positively correlated with the stages of fibrosis.The areas under receiver operating characteristic curve （AUC）of CTGF,PDGF-BB and sICAM-1 were 0.817,0.765,and 0.733,respectively.The conjoined detection of CTGF,PDGF-BB,and sICAM-1 could improve the accuracy of diagnosis of liver fibrosis.Conclusions Serum CTGF,PDGF-BB,and sICAM-1 are the indicators for predicting the stage of liver fibrosis,which could be used as valuable markers in assessing liver fibrosis.
出处
《实用预防医学》
CAS
2010年第6期1060-1062,共3页
Practical Preventive Medicine
基金
湖南医药卫生科研计划项目(B2009137)
关键词
肝纤维化
结缔组织生长因子
血小板衍生生长因子-BB
可溶性细胞黏附分子-1
Hepatic fibrosis
Connective growth tissue factor （CTGF）
Platelet-derived growth factor-BB （PDGF-BB）
Soluble intercellular adhesion molecule-1 （sICAM-1）
