摘要
目的观察口服孟鲁司特钠治疗咳嗽变异性哮喘的效果。方法 86例咳嗽变异性哮喘患儿行诊断性治疗后,随机分为治疗组46例,口服孟鲁司特钠;对照组40例,吸入丙酸氟替卡松,共6个月,观察用药期间咳嗽缓解情况。疗程结束,随访6个月,观察复发情况。统计有效率、有效患儿症状开始至治疗开始时间(治疗前有症状日)、随访6个月的复发率。结果治疗组46例,有效40例,有效率86.9%,无效6例(加吸入糖皮质激素治疗后4例咳嗽缓解);对照组40例,有效35例,有效率87.5%,无效5例(加孟鲁司特钠治疗后咳嗽缓解);疗程结束,随访6个月,治疗组及对照组均有4例复发。有效率和复发率两组比较差异无统计学意义(P>0.05)。治疗有效患儿治疗前病程明显短于无效患儿(P<0.05)。结论口服孟鲁司特钠与吸入丙酸氟替卡松治疗咳嗽变异性哮喘疗效相当,且疗效与患儿病程长短有关,前者使用更方便。少部分需联合用药,可能与CVA部分患儿在其慢性咳嗽的发病机理中与多种因素参与有关。
Objective To evaluate the clinical therapeutic effect of montelukast on cough variant asthma.Methods After diagnostic therapy,86 children with cough variant asthma were randomly divided into therapy group （treated with oral montelukast,n=46） and control group （treated with inhaled fluticasone,n=40）.Cough relaxation was observed during 6 months treatment.All patients were followed up 6 months after therapy to observe the relapse,evaluate the treatment efficiency,and count the days that patients had symptoms before treatment.The relapse rate after 6 months treatment was followed up.Results There were 40 effective patients and 6 ineffective patients （4 patients’ cough relaxation was observed after inhaling fluticasone） in therapy group,with the effective rate of 86.9%.There were 35 effective patients and 5 ineffective patients （cough relaxation was observed after receiving oral montelukast） in control group,with the effective rate of 87.5%.All patients were followed up 6 months after therapy.There were 4 patients of therapy group and 4 patients of control group recurred.No statistically significant difference was found in effective rate and relapse rate between the two groups （P0.05）.The days that patients had symptoms before treatment in effective patients were significantly less than those in ineffective patients （P〈0.05）.Conclusions The therapeutic effects of the two groups are similar,but it is more convenient to use montelukast.The therapeutic efficacy is correlated with the duration of the disease.Some patients need combined drugs,perhaps not only related with leukotriene,but also with many factors.
出处
《实用预防医学》
CAS
2010年第6期1173-1174,共2页
Practical Preventive Medicine
