摘要
目的：研究肝动脉插管自体骨髓干细胞移植对肝硬化失代偿和慢性重症肝病的治疗作用。方法：从患者髂后上棘抽取骨髓100~200 m l,分离纯化骨髓源性干细胞,行肝动脉介入将干细胞移植到肝脏。观察移植后的临床症状、术后不良反应、肝功能检测及2年的生存率。结果：自体骨髓干细胞移植后患者症状好转,肝功能明显改善,生存率提高,未发现严重并发症。结论：骨髓干细胞移植对肝硬化失代偿的治疗安全有效,可作为肝硬化失代偿和慢性重症肝病的一种新的治疗方法。
Objective：To investigate the effect of autologous bone marrow stem cells transplantation in the treatment of decompensated liver cirrhosis.Methods：Bone marrow was aspirated from posterior superior iliac spine.After isolation and purification,the stem cells were transplanted into liver via hepatic artery.The clinical symptoms,adverse reaction,liver function and 2-year survival rate were observed after transplantation.Results：After transplantation,the clinical symptoms and liver function were improved,and the 2-year survival rate was increased.No severe complication related with transplantation was observed.Conclusion：Transplantation of autologous myeloid stem cells is a safe and effective method in the treatment of decompensated cirrhosis.
出处
《西北国防医学杂志》
CAS
2010年第3期187-189,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
肝硬化
骨髓干细胞
移植
Liver cirrhosis
Myeloid stem cells
Transplantation
