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原发性高血压病患者TNF-α与IR的关联分析

Relationship Between Increased Serum Tumor Necrosis Factor Levels and Insulin Resistance in Patients with Essential Hypertension
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摘要 目的:探讨原发性高血压病患者肿瘤坏死因子-α(TNF-α)与胰岛素抵抗(IR)的关联。方法:应用放免法测定41例原发性高血压病患者和38例正常对照组的血清TNF-α及胰岛素(fINS)水平,用胰岛素抵抗指数(HOMA-IR)评价IR程度。结果:高血压组病血清TNF-α水平显著高于正常对照组(P<0.001);HOMA-IR显著高于正常对照组(P<0.001),相关分析显示,在高血压病组及正常对照组中,TNF-α与BMI、HOMA-IR、收缩压(SBP)呈正相关(P<0.05)。结论:高血压病患者血清TNF-α升高,且与肥胖及IR呈正相关。 Objective To investigate the relationship between serum tumor necrosis factor-α(TNF-α)levels and insulin resistance(IR)in patients with essential bypertension.Methods Serum TNF-α and free insulin(fINS)levels were measured with RIA in 41 patients with essential hypertension and 38 controls.Insulin resistance was calculated with insulin resistance index(HOMA-IR).Results The serum TNF-α levels were significantly higher in patients with essential hypertension than those in the controls(P0.001).The HOMA-IR was also significantly higher in hypertension group than that in controls(P0.001).Serum TNF-α levels was positively correlated with BMI,HOMA-IR and SBP both in hypertension group and control group(P0.05).Conclusion Serum TNF-α level was increased in hypertensive patients and positively correlated with obesity and IR.
出处 《放射免疫学杂志》 CAS 2010年第3期249-250,共2页 Journal of Radioimmanology
关键词 肿瘤坏死因子-Α 胰岛素抵抗 高血压 tumor necrosis factor-α insulin resistance hypertension
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参考文献4

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二级参考文献4

  • 1陈明卫,王佑民,胡红琳,胡国平,刘玲,王长江,杨明功.血清肿瘤坏死因子α、游离脂肪酸以及抵抗素与2型糖尿病患者胰岛素抵抗的关系[J].中国糖尿病杂志,2006,14(1):4-6. 被引量:26
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  • 4Bruun JM, Lihn AS, Verdich C, etal. Regulation of adlponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab, 2003,285: E527-E533.

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