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慢性心功能不全患者血浆骨桥蛋白水平与房颤的相关性研究

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摘要 目的探讨骨桥蛋白(osteopontin,OPN)与心力衰竭患者中心房颤动(atrial fibrillation,AF)的相关性。方法慢性心功能不全患者179例。根据有无房颤发生分为2组,房颤组(AF,n=88)和窦律组(SR,n=91),检测血浆OPN及高敏C反应蛋白水平。结果慢性心功能不全患者中AF组血浆OPN水平显著高于SR组(554±178ng/Lvs.399±192ng/L,P=0.014)。hsCRP在AF组患者中的水平亦显著高于SR组(3.79±0.34ug/Lvs.2.67±0.56ug/L,P=0.031)。血浆OPN与hsCRP具有显著相关性(r=0.048,P<0.001)。OPN与AF的发生呈显著正相关(r=0.548,P<0.001)。结论血浆OPN与慢性心衰患者AF的发生率相关。
出处 《心脑血管病防治》 2010年第3期212-213,共2页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
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