摘要
为了探讨菊苣胶囊防治糖尿病的作用机理，采用体内实验方法，观察本药对正常小鼠及不同高血糖模型小鼠血糖的影响。结果发现，该药物对正常小鼠血糖无明显作用；但可显著降低四氧嘧啶及肾上腺素模型小鼠血糖含量；同时升高肾上腺素模型小鼠肝糖原含量。初步表明，菊苣胶囊降糖作用与胰外途径有关，尤其是与增加肝糖原含量、减少肝糖原分解作用密切相关。
To discuss the mechanism of preventive and curative action of the Chicory Capsule on diabetes, taking test in vivo, we observe the effects on the normal mice and the different hyperglycemic mice models respectively. The results show the medicine has no significant effect on the blood glucose of normal mice, but could markedly decrease it of the alloxan and adrenalin mice model and at the same time increase the amount of hepatic glycogen of the adrenalin mice model. It preliminarily indicates that, the blood glucose lowering action of the Chicory Capsule correlates with the extra-pancreas route, especially it can increase the amount of hepatic glycogen and inhibit the decomposition.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
1999年第1期28-30,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家科委医药技术创新博士项目
关键词
菊苣胶囊
药理
血糖
肝糖原
实验药理
降血糖
Chicory Capsule
Pharmacology
Blood glucose
Hepatic glycogen
mouse
