摘要
为研究胃癌组织中ｎｍ２３的表达与淋巴结转移及预后的关系，我们应用Ｓ－Ｐ免疫组化技术对１０５例胃癌ｎｍ２３表达进行观察，并对其中５９例患者随访。结果显示ｎｍ２３蛋白阳性表达率为４４８％，ｎｍ２３在胃癌的表达与分化，浸润深度、临床分期有关（Ｐ＜００５），淋巴结转移阴性组的阳性率表达（７０９％）与阳性组比较（３３８％）差异有显著意义（Ｐ＜００５），随访资料证实ｎｍ２３表达与患者预后有非常显著意义（Ｐ＜００１）。提示ｎｍ２３基因产物的表达可作为一个淋巴结转移和判断预后有用的指标。
To study the relationship between expression of nm23 in gastric carcinoma and lymph node metastasis and prognosis.Expressions of nm23 in 105 cases of gastric carcinoma were observed by immunohistochemistry.Among them,59 cases were followed up.The incidences of nm23 protein positivity in gastric carcinomas were 44 8%.The results showed that 70 9% of gastric cancers without lymph node metastasis was nm23 protein expression and 33 8% of gastric cancers with lymph node metastasis was nm23 protein lower-expression ( P<0 05) .The expression of nm23 protein in human gastric carcinomas tissues was related to the differentiation,depth of invasion,TNM stage ( P<0 05) .Analysis of patient survival demonstrated that the prognosis of gastric cancer with nm23 protein expression was significantly better than those without ( P<0 01) .These findings indicate that nm23 protein may be a good marker of lymph node metastasis and prognosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第1期30-32,共3页
Cancer Research on Prevention and Treatment
