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信号转导子和转录激活子4与支气管哮喘 被引量：3

Signal transducer and activator of transcription 4 and bronchial asthma
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摘要 支气管哮喘是多种细胞特别是嗜酸性粒细胞、肥大细胞、T淋巴细胞、中性粒细胞和气道上皮细胞及其细胞成分参与的气道慢性炎症性疾病,以气道炎症、可逆的气道阻塞和气道高反应性为其特征。信号转导子和转录激活子4(signal transducer and activator of transcription 4,STAT4)作为一种新型的能与靶基因调控区DNA结合的转录因子,介导白介素12的免疫反应与调节T细胞的分化,调节促炎因子与抗炎因子的应答,可能在支气管哮喘中发挥重要作用。该文从STAT4的基因位点、结构、信号转导途径及其与支气管哮喘的关系进行综述。 Bronchial asthma is a chronic inflammatory disease of airways.A variety of cells,especially eosinophils,mast cells,T lymphocytes,neutrophils,airway epithelial cells and cellular components take part in bronchial asthma.Bronchial asthma is characterized by airway inflammation,reversible airflow obstruction,and airway hyper-responsiveness.Signal transducer and activator of transcription 4（STAT4） acted as a new type transcription factor,binding to specific DNA-response elements in the promoters of target genes,mediated the immune response of IL-12 and regulated T cell differentiation,modulated pro-and anti-inflammatory responses.It may play an important role in bronchial asthma.This review summarized STAT4 gene locus,constitution,signal transduction pathway and the relationship between STAT4 and asthma.
作者 李美容 王敏
机构地区 三峡大学第一临床医学院
出处 《生命的化学》 CAS CSCD 北大核心 2010年第3期413-416,共4页 Chemistry of Life
关键词 支气管哮喘 信号转导子和转录激活子4 气道高反应性 bronchial asthma STAT4 airway hyperresponsiveness
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献23

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二级参考文献15

共引文献13

同被引文献42

  • 1李利清,霍莉莉,张新光,虞坚尔.支气管哮喘与Th1/Th2失衡研究进展[J].中西医结合学报,2005,3(5):403-407. 被引量：22
  • 2于欣,熊瑛.信号转导及转录激活子-1与支气管哮喘[J].国际呼吸杂志,2007,27(10):758-760. 被引量：4
  • 3陈晓红,钟南山,张卫东,曹智臻,何梦璋,罗群,任筱兰,李时悦,Li L.布地奈德对哮喘小鼠气道重塑及JAK1/STAT6表达的影响[J].中华医学杂志,2007,87(23):1627-1632. 被引量：30
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  • 10Hsieh Y Y,Wan L,Chang C C,et al.STAT2 C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma[J].Int J Biol Sci,2009,5(1):74-81.

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二级引证文献9

生命的化学
2010年 第3期

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