摘要
合成了3个水杨醛Schiff碱氧钒配合物.采用元素分析、红外光谱和51VNMR谱等对配合物结构进行了表征.并进行了载药脂质体的粒径粒度分析和表观形貌观察,比较研究了配合物及载药脂质体的红外光谱和肝肿瘤细胞的抑制作用.结果表明:在氧钒配合物脂质体的红外光谱中,氧钒配合物的特征振动峰仍然存在,在载药脂质体形成后,氧钒配合物的基本骨架没有发生变化,但由于弱相互作用导致V=O振动峰增强并发生蓝移;随着试药浓度的增加,配合物和载药脂质体对肿瘤细胞的抑制率均明显增加,但同浓度的配合物和载药脂质体比较,前者对肝肿瘤细胞的抑制能力明显低于后者,可能与载药脂质体具有更强的细胞钻透能力有关,而更易于将药物传输到作用部位.
Three Schiff base oxovanadium complexes have been synthesized and characterized with element analyses,IR and 51V NMR spectrum.They have been studied that the particle size of drug-loaded liposome and the apparent morphology.IR spectrum and inhibition of liver tumor cells of the complex and the drug-loaded liposomes were comparatived.The results showed that the characteristic vibrational peaks of oxovanadium complexes drug-loaded liposome in IR spectrum still exist.The results suggested that the basic framework of the oxovanadium complexes has not changed drug-loaded,but because weak mutual interaction leading enhanced and caused displacement of νas（V=O）vibration.The results also show that the lower concentration of the complexes and drug-loaded liposomes,the smaller the inhibition rate of tumor cells.The inhibition rate of the same concentration of complexes and drug-loaded liposome was significantly lower than the latter,and may be related to drug-loaded liposomes have a stronger ability to drill through the cells,and more easily transferred to the effects of drugs on site.
出处
《东北师大学报（自然科学版）》
CAS
CSCD
北大核心
2010年第2期91-96,共6页
Journal of Northeast Normal University(Natural Science Edition)
基金
国家自然科学基金资助项目(20872013)
