摘要
目的:观察慢性工频磁场(extremely low frequency magnetic field,ELF-MF)暴露对大鼠神经行为的影响。方法:应用50Hz正弦交变磁场,2mT的暴露强度在每日一定时间对大鼠进行多次重复暴露。大鼠被随机分为对照组(不暴露MF)、MF1h组(每日MF暴露1h)及MF4h组(每日MF连续暴露4h),通过大鼠旷场实验、高架十字迷宫实验、明暗穿梭箱实验观察大鼠的行为变化情况。结果:与对照组相比,MF4h组大鼠在旷场实验中趋触性增高、理毛行为增多,在高架十字迷宫中开放臂入臂次数和停留时间均明显减少;MF1h组与对照组相比差异无统计学意义。在明暗箱实验中,暴露组与对照组的差异无统计学意义。结论:极低频磁场暴露对大鼠有产生焦虑的作用,这种影响取决于每日暴露的时间。
Objective：To observe the effect of chronic exposure to extremely low frequency magnetic field on neurobehavioral of adult rats.Methods：Fifty Hz sinusoidal extremely low frequency magnetic field（ELF-MF）was used in this experimental procedure and the strength of magnetic field was fixed at 2 mT.Thirty male adult rats were divided randomly into 3 groups：（1）no ELF MF exposure（control group,n=10）;（2）exposure to ELF MF 1 h/day（MF1h group,n=10）;（3）exposure to ELF MF 4 h/day（MF4h group,n=10）.The neurobehavioral changes of rats were detected by the open field test,elevated plus maze test and light/dark box test.Results：Compared with controls,no significant difference was found in rats of MF1h group in any test.Rats in MF4h group showed increased thigmotaxis,more grooming in the open field test;less time spent in open arms,central part and more time spent in closed arms.However,no significant difference was observed in the light/dark test in MF1h or MF4h group.Conclusion：Chronic ELF MF exposure has an anxiogenic effect on rats,which is dependent on the daily exposure duration.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2010年第3期351-355,共5页
Journal of Peking University:Health Sciences
基金
职业病防治技术标准研究项目(2002BA906A63)资助~~
关键词
磁场
环境暴露
焦虑
迷宫学习
大鼠
Magnetic fields
Environmental exposure
Anxiety
Maze learning
Rats
