摘要
分类介绍作用于血管内皮细胞生长因子信号通路的血管生成抑制剂研究近况以及该类药物存在的缺陷。血管生长促进因子和血管抑制因子的活性及其表达水平对肿瘤的发生和发展具有关键性的作用,所以,针对于血管生成,尤其是靶向于血管内皮细胞生长因子的药物已成为近年来抗肿瘤药物研究的热点之一。
Vascular endothelial growth factor（VEGF） signaling pathway-targeted inhibitors were introduced.Tumor growth,invasion and metastasis are all blood vessel-dependent but the activity and expressing level of blood vessel growth-promoting factors and inhibiting factors are considered to be the most important to angiogenesis.In recent years,the cancer therapy has focused on developing molecular targeted drugs,especially angiogenesis-targeted drugs,such as VEGF signaling pathway-targeted inhibitors.
出处
《药学进展》
CAS
2010年第6期256-263,共8页
Progress in Pharmaceutical Sciences
基金
国家"重大新药创制"科技重大专项(No.2009ZX09103-654)
