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18F—FLT及18F—FDG监测肺癌化疗后早期反应的动物实验 被引量：6

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摘要 18F-脱氧葡萄糖（nuorodeoxyglucose，FDG）在肺癌的诊断及疗效监测中有重要的作用，但特异性较差，存在一定的假阳性.18F-脱氧胸腺嘧啶核苷（fluorothymidine，FLT）是核酸代谢显像剂。笔者观察了经紫杉醇＋顺铂治疗后1d的荷肺癌裸小鼠的18F—FLT和18F—FDG生物分布，
作者 李红梅 冯珏 张锦明 张建阳 李晓东 方凤宁 王亚平
机构地区 河北医科大学第二医院核医学科 解放军总医院核医学科
出处 《中华核医学杂志》 CAS CSCD 北大核心 2010年第3期194-194,共1页 Chinese Journal of Nuclear Medicine
基金 基金项目：河北省2008年医学科学研究重点课题计划（08090）
关键词 18F-脱氧葡萄糖 疗效监测 FDG FLT 动物实验 早期反应 肺癌 化疗后
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献2

  • 1王中秋,吴江,朱虹,常林风,陈英鑫,卢光明.PET／CT对肺部肿块的诊断[J].中华核医学杂志,2009,29(1):19-22. 被引量：9
  • 2Dittmann H,Dohmen BM,Kehlbach R,et al.Early changes in 18F-FLT uptake after chemotherapy:an experimental study.Eur J Nucl Med Imaging,2002,29:1462-1469.

二级参考文献7

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共引文献8

同被引文献106

  • 1张晓丽,曹国宪,俞惠新,金坚.延胡索乙素对人乳腺癌细胞MCF-7摄取~99Tc^m-MIBI的影响[J].中华核医学杂志,2006,26(5):313-313. 被引量：11
  • 2Shields AF, Grierson JR, Dohmen BM, et al. Imaging proliferation in vivo with ^18F-FLT and positron emission tomography. Nat Med, 1998, 4: 1334-1336.
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  • 6Rasey JS, Grierson JR, Wiens LW, et al. Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells. J Nucl Med, 2002, 43: 1210-1217.
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  • 8Vesselle H, Grierson J, Muzi M, et al. In vivo validation of 3'deoxy-3'-^18F-fluorothymidine (^18F-FLT) as a proliferation imaging tracer in humans: correlation of ^18F-FLT uptake by positron emission tomography with Ki-67 immunohistoehemistry and flow eytometry in human lung tumors. Clin Cancer Res, 2002, 8: 3315-3323.
  • 9Yamamoto Y, Nishiyama Y, Ishikawa S, et al. Correlation of ^18F- FLT and is F-FDG uptake on PET with Ki-67 immunohistochemistry in non-small cell lung cancer. Eur J Nucl Med Mol Imaging, 2007, 34 : 1610-1616.
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引证文献6

二级引证文献10

中华核医学杂志
2010年 第3期

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