摘要
目的研究大剂量一氧化氮对大鼠痛阈的影响，分析其可能的作用机制。方法以钾离子透入引起大鼠甩尾反应的电流强度作为痛反应指标，观察侧脑室注射大剂量Ｌ－精氨酸，对大鼠基础痛阈的影响。结果大鼠侧脑室内注射Ｌ－精氨酸１６０ｍｍｏｌ，首先即刻表现为明显的痛敏效应，此后大鼠痛阈逐渐回升，１５ｍｉｎ后大鼠痛阈升高非常显著。而侧脑室注射小剂量Ｌ－精氨酸，大鼠仅显示出明显的痛敏作用。结论大剂量Ｌ－精氨酸对大鼠痛阈的影响呈显著地双相效应。
Objective To study of the roles of large dose L-arginine (L-Arg) which was injected into cerebral ventricular of rats in pain threshold(PT).Methods With the use of potassium inotophoresis induced tail-flick for measuring the pain threshold of rats. The precursor of nitric oxide(NO) which was L- Arg was injected into cerebral ventricular of rats . The effects of large dose L- Arg on pain threshold was investigated in rats.Result Large dose L- Arg (160 mmol) administration attenuated inmediately( 2 min) the pain threshold; then the pain threshold was increased gradualy. After injection 15 min, the pain threshold was enhanced signifcantly compared with that of control groups. In addition, that the pain threshold decreased remarkably by microinjecting L-Arg(20 mmol) was observed. Conclusion The results suggested that large dose L- Arg by injected into cerebral ventricular may be play a dual role in pain threshold in central nervous system of rats.
出处
《济宁医学院学报》
1999年第1期1-4,共4页
Journal of Jining Medical University
基金
山东省教育委员会资助
关键词
L-精氨酸
痛
痛阈
一氧化氮
L-arginine,Pain,pain threshold,Nitric oxide
