摘要
目的:总结国内外关于微小RNA与肿瘤的发生发展,以及诊断和治疗相关的研究进展。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"微小RNA、肿瘤"为关键词,检索2005-01-2010-01的文献,共检索到英文文献541篇,中文文献37篇。纳入标准:1)miRNA在肿瘤的诊断和预后判断中的作用;2)miRNA在肿瘤发生发展中的作用;3)miRNA在肿瘤治疗中的应用。共96篇文献符合纳入标准,最后纳入分析27篇文献。结果:微小RNA在细胞的多种生命活动,如增殖、分化、凋亡中发挥着重要的调节作用,因而在不同肿瘤中能够发挥癌基因或者抑癌基因的作用。通过检测组织或者患者血液及血清中微小RNA表达情况的变化可以作为肿瘤诊断和预后的指标。结论:深入研究微小RNA在肿瘤的发生发展中所起的作用,有望在肿瘤的诊断和靶向治疗以及预后判断方面提供新的思路。
OBJECTIVE：To summarize the research of miRNA in tumor carcinogenesis,diagnosis,prognosis and anti-tumor therapy.METHODS：By PUBMD and CNKI retrieval system,with miRNA and neoplasm as the key words,541 papers of literature in English and 37 in Chinese were retrieved from 01,2005 to 01,1010.The selection standards for the data related to miRNA：1） in tumor diagnosis and prognosis;2）the role of miRNA in carcinogenesis and tumor progression 3） anticancer therapy using miRNA.According to the above standards,96 documents were selected and 27 were finally analyzed.RESULTS：miRNA are involved in numerous cellular processes including proliferation,differentiation and apoptosis.And miRNA can take effect as oncogene or tumor suppresser in different cancers.A large body of evidence has demonstrated that deregulated miRNA correlates closely with carcinogenesis and tumor progression as well as cancer prognosis.CONCLUSION：Further research on the molecular mechanism of miRNA in carcinogenesis and tumor progression will provide new clue in tumor diagnosis and anticancer therapy.
出处
《中华肿瘤防治杂志》
CAS
2010年第7期547-550,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
微RNAS
肿瘤
综述文献
microRNAs
neoplasms
review literature
