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血管紧张素转化酶2作为心血管纤维化干预新靶点 被引量：4

Angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular fibrosis
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摘要 血管紧张素转换酶2(ACE2)是人类ACE的第一个同源基因,为心血管纤维化的防治提供了新的作用靶点。本文就ACE2基因的生物学特性、ACE2与心血管纤维化调控以及心血管纤维化防治的最新进展作一综述。 Angiotensin-converting enzyme 2（ACE2） is the first human homologue of ACE,being a new therapeutic target for cardiovascular fibrosis and remodeling.This review focuses on the biological features of ACE2,ACE2 and its modulation in process of cardiovascular fibrosis as well as the latest advance in prevention and treatment of cardiovascular fibrosis.
作者 吴玮 钟久昌 郭俊明
机构地区 宁波大学医学院分子高血压病研究室 上海交通大学医学院瑞金医院高血压研究所
出处 《基础医学与临床》 CSCD 北大核心 2010年第7期778-781,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(30700328 30973522) 浙江省科技计划面上科研项目(2009C33080)
关键词 血管紧张素转换酶2 心血管纤维化 血管紧张素Ⅱ 重塑 angiotensin-converting enzyme 2 cardiovascular fibrosis angiotensin Ⅱ remodeling
分类号 R544.109 [医药卫生—心血管疾病]
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参考文献19

  • 1Krum H, Gilbert RE. Novel therapies blocking the reninangiotensin-aldosterone system in the management of hypertension and related disorders [ J ]. J Hypertens, 2007, 25 (1) :25 -35.
  • 2Kassiri Z, Zhong Jiuchang, Guo Danny, et al. Loss of angiotensin-eonverting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction [J]. Circ Heart Fail, 2009, 2(5) :446 -455.
  • 3Mereure C, Yogi A, Callera GE, et al. Angiotensin ( 1-7 ) blunts hypertensive cardiac remodeling by a direct effect on the heart[J]. Circ Res, 2008, 103(11): 1319 -1326.
  • 4Raizada MK, Ferreira AJ. ACE2: a new target for cardiovascular disease therapeutics[J]. J Cardiovasc Pharmacol, 2007, 50(2) :112 - 119.
  • 5Gallagher PE, Ferrario CM, Tallant EA. Regulation of ACE2 in cardiac myocytes and fibroblasts[J]. Am J Physiol Heart Circ Physiol, 2008, 295(6) :2373 -2379.
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  • 7Bennett RG. Relaxin and its role in the development and treatment of fibrosis [J]. Transl Res, 2009, 154( 1 ) :1 - 6.
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二级参考文献23

  • 1钟久昌,朱鼎良.血管紧张素转换酶2与高血压[J].高血压杂志,2005,13(11):682-686. 被引量：20
  • 2郑琼莉,毛莉娜,祝炜,贾晶.高血压心肌纤维化影响因素及临床诊断[J].心血管康复医学杂志,2007,16(3):310-312. 被引量：11
  • 3Grebe JL, Mecca AP, Lingis Met al. Prevention of angiotensin Ⅱ-induced cardiac remodeling by angiotensin- (1-7) [J]. Am J Physiol Heart Circ Physiol, 2007, 292 (2): H736-742.
  • 4Stewart JA,Lazartigues E, Lucchesi, et al. The angiotensin con verting enzyme 2/Ang-(1-7) axis in the heart;A role for mas communication[J]? Cire Res,2008,103 (11) :1197-1199.
  • 5Tallant EA, Ferrario CM, Gallagher PE. Angiotensin- (1-7) inhibits growth of cardiac myocytes through activation of the mas receptor [J]. Am J Physiol Heart Circ Physiol, 2005, 289 (4): H1560-1566.
  • 6Raizada MK, Ferreira AJ. ACE2: a new target for cardiovascular disease therapeutics [J].J Cardiovasc Pharmacol, 2007, 50 (2): 112-119.
  • 7Sarkissian SD, Grobe JL, Yuan LH, et al. Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology [J]. Hypertension, 2008, 51 (3): 712-718.
  • 8Jin D, Takai S, Sugiyama T, et al. Long-term angiotensin Ⅱ blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis [J]. 2009, 109 (2) : 275-284.
  • 9MercureC, Yogi A, Callera GE, et al. Angiotensin (1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart [J]. Circ Res, 2008, 103 (11): 1319-1326.
  • 10Zhong JC, Yu XY, Lin QX, et al. Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of maerophage migration inhibitory factor expression [J]. BrJ Pharmacol, 2008, 153 (1): 66-74.

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基础医学与临床
2010年 第7期

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