摘要
对b型流感嗜血杆菌结合疫苗冻干剂型进行了研制。选用2.5%的甘氨酸作为稳定剂对疫苗进行冻干,对冻干疫苗的抗原性、免疫原性和安全性等理化特性和免疫学特性进行了检定,并与同类疫苗进行比较。各项检定结果及系统观察表明:冻干疫苗安全性良好,抗原性及免疫原性没有发生改变。与同类疫苗相比,针对HibCPS抗原的IgG抗体及针对TT抗原的抗体水平具有相同的变化趋势。冻干疫苗稳定性较冻干前明显变好,效期可延长至3年;不仅有利于保存和运输,而且方便与其他疫苗联合使用。
The freeze-dried Haemophilus influenza type b （ Hib ） polysaccharide protein conjugate vaccine was developed. The vaccine was freeze-dried using 2.5% glycine as a stabilizer. The properties, the antigenicity, immunogenicity, safety and physical-chemical properties of the freeze-dried vaccine were detected by comparison with other similar vaccines. The results showed that the freeze-dried vaccine is of excellent safety and there are no changes in antigenicity and immunogenici- ty. Comparing with the liquid vaccine, the titer changes of anti-Hib CPS IgG and anti-q3＂ antibody are similar. The stability of freeze-dried vaccine is better, and the term of validity can be prolonged to three years.
出处
《微生物学免疫学进展》
2010年第2期1-8,共8页
Progress In Microbiology and Immunology
