摘要
目的探讨雌激素在延髓头端腹内侧部（RVM）对内脏痛的潜在调节作用。方法采用成年雌性大鼠,在浅麻醉状态下记录充胀直肠（CRD）引起的腹肌放电活动,即内脏运动反应（VMR）;RVM局部和小脑延髓池给予雌激素和（或）吗啡,观察VMR变化。结果 RVM部位微量注射雌激素（0.01~1μmol/L,0.5μL）可剂量依赖性地增强CRD引起的VMR,这一作用的潜伏期〈2 min;小脑延髓池给予雌激素（0.1~1μmol/L,50μL）可以拮抗RVM部位给予吗啡对VMR的抑制效应,该拮抗效应随雌激素浓度的升高而增强。结论雌激素作用于RVM部位,不仅使VMR增强,还可以拮抗吗啡的中枢镇痛作用。
Objective To examine the potential roles of estrogen in rostral ventromedial medulla（RVM） on visceral nociception.MethodsThe visceromotor responses（VMR） evoked by repeated colorectal distention（CRD） were monitored in lightly anesthetized adult female rats.Various doses of estrogen or morphine were applied by microinjection into RVM or cerebellomedullary cistern,and the changes of VMR were observed.ResultsLocal administration of estrogen in RVM（0.01-1 μmol/L,0.5 μL） resulted in dose-dependent increments in VMR evoked by CRD,with 2 min for the latency of this effect.Moreover,estrogen（0.1-1 μmol/L,50 μL）applied intracisternally dose-dependently blocked the analgesia induced by microinjection of morphine into RVM.ConclusionEstrogen acting in RVM may not only enhance VMR,but also antagonize the analgesic action of morphine.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第6期674-678,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
教育部留学回国人员启动基金
上海市卫生局青年科研基金(2007Y44)~~
关键词
雌激素
延髓头端腹内侧部
内脏运动反应
内脏痛
estrogen
rostral ventromedial medulla
visceromotor response
visceral pain
