摘要
目的:探讨血清中IL-1β、IL-2、IL-10三种炎症细胞因子含量与治疗前后慢性非细菌性前列腺炎(CAP)的关系。方法:用双抗夹心ELISA法测定65例CAP患者治疗前后前列腺液和血清中IL-1β、IL-2、IL-10的含量,并且以25例健康男性作为对照。利用统计软件SPSS对实验数据进行统计学分析。结果:治疗前CAP组前列腺液和血清中IL-1β、IL-2、IL-10水平明显高于对照组(P<0.05);治疗后CAP组前列腺液和血清中IL-1β、IL-2、IL-10的水平较治疗前明显降低(P<0.05)。结论:IL-1β、IL-2、IL-10三种炎症细胞因子可能在CAP疾病的病理生理过程中发挥了重要的作用,测定三种炎症细胞因子的表达水平对于CAP的诊断和临床疗效评价具有一定的应用价值。
Objective:To investigate the relationship between interleukin(IL)-1β,IL-2 and IL-10 with chronic abacterial prostatitis(CAP)by measuring the concentrations of the three Cytokines in the CAP patients ' serum and prostatic fluid pre and post treatment.Methods:the leves of IL-1β,IL-2 and IL-10 in the serum and prostatic fluid were detected by double sandwich ELISA in 65 CAP pa-tients,and 25 healthy males as control.The results were analyzed by SPSS statistic software.Results:Before the treatment,the levels of the three cytokines in serum and prostatic fluid were significantly higher than those in control group(P0.05);after the treatment,the levels of the three cytokines were significantly lower than those in pre treatment(P0.05).Conclusion:IL-1β,IL-2 and IL-10 may play an important role in the pathophysiological process of CAP,and their levels may have applicable value in the diagnosis and therapeutic evaluation of CAP.
出处
《现代医药卫生》
2010年第13期1954-1956,共3页
Journal of Modern Medicine & Health