摘要
目的 研究系统性红斑狼疮（SLE）患者外周血T辅助细胞17（Th17）的变化,并与病情活动性及脏器损害等临床资料进行相关性分析,探讨Th17在SLE发病中的作用.方法 选择20例SLE患者,根据SLEDAI评分及有无蛋白尿、肾功能损害等进行分组;同时选择类风湿关节炎（RA）患者和健康者为对照,采用流式细胞术检测Th17细胞的阳性表达百分率.结果 SLE患者外周血Th17阳性表达百分率高于健康对照组,而RA患者明显高于SLE组及健康对照组（P＜0.05）.Th17阳性表达百分率在SLE病情活动组较非活动组升高（P＜0.05）,在狼疮性肾炎（LN）患者中有肾功能损害者高于无肾功能损害者（P＜0.05）,且与24小时尿蛋白定量正相关（P＜0.05）,并与血小板计数及抗ds-DNA抗体滴度有相关性（P＜0.05）.结论 Th17可能参与SLE的发病过程,且与其病情活动性、肾脏损害程度及蛋白尿相关,亦影响SLE患者血小板及抗dsDNA抗体.
Objective To investigate the Th17 lymphocytes in the peripheral blood of systemic lupus erythematosus（SLE） patients, analyze the correlation with clinical data, disease duration, severity and internal organs damage, evaluate their influence in the pathogenesis of SLE. Methods 20 cases of SLE patients were divided into groups according to SLEDAI points, proteinuria and renal function damagement. Meanwhile, rheumatoid arthritis （RA） Patients and healthy adults were chosen as the control groups. How cytometry（FCM） was used to detect Th17 lymphocytes expression percentage. Results Peripheral Th17 lymphocytes increased in SLE group compared to healthy control group, but those in RA group are higher than both SLE group and healthy control group （P 〈 0.05 ）. Meanwhile, Th17 lymphocytes appeared disparities between active and inactive group（ P 〈 0. 05 ）. Those with renal function damage were more than undamaged among LN group （ P 〈 0. 05 ）, and show positive correlation ration with 24 hours urine albumen. Correlation existed between Th17 lymphocytes and platelets, anti-dsDNA antibody titers as well （P 〈 0.05）. Conclusion Th17 lymphocytes may be involved in the pathogenesis of SLE. They are associated with disease activity, renal damage extent and albuminuria, and also impact on patients＇ platelets and antidsDNA antibodies.
出处
《临床内科杂志》
CAS
2010年第6期391-393,共3页
Journal of Clinical Internal Medicine
基金
项目基金：安徽省人事厅外国专家局聘请外国专家项目（No.20083400221）
关键词
红斑狼疮
狼疮性肾炎
T辅助细胞17
Lupus erythematosus, systemic
Lupus nephritis
T Helper Cells 17
