摘要
目的为探讨肝病患者血清ＨＡ、ＰＣⅢ、ＬＮ联合检测诊断肝纤维化的临床意义。方法采用放射免疫方法对１６７例肝病患者血清ＨＡ、ＰＣⅢ、ＬＮ水平进行检测与分析。结果各肝病组血清三项指标水平均较对照组有不同程度的升高，尤以慢性肝炎中度组升高显著，与对照组有显著性差异（Ｐ＜０．０５、０．０１）；三项指标水平在慢性肝病呈规律性改变，表现为慢性肝炎轻度→中度→重度→肝硬化依次增高。其增高的幅度和肝组织病理检查所见肝纤维化增生程度有较好的同步关系。结论三项指标均可反映肝脏损伤病变活动程度及肝纤维化的发展趋势；联合检测可从不同角度更好地反映肝病慢性化的程度，提高肝纤维化诊断的准确性和可靠性。
Objectives To study the clinical significance of diagnosis in liver fibrogenesis by simultaneously testing the serum contents of HA,PCⅢ and LN.Methods RIA was performed in 167 patients with chronic liver disease to determine the serum levels of HA,PCⅢ and LN.Results Showed that the levels of HA,PCⅢ and LN were significanthy higher in different liver disease groups than that in control group especially in those groups after moderote stage ( P <0.05or 0.001).The level of moderate severe hepatitis and liver cirrhosis groups order.The degree of increased level of the three indexes is correlation with that of pathological proliferation of liver fibrogenesis.Conclusions The study indicated that simultancously testing three inclexes can reflect the degree of liver disease oltivity the developing trend of the liver fibrogensis,and improved the diagnosis accuraly and veliability of the liver fibrogensis
出处
《宁夏医学杂志》
CAS
1999年第1期10-11,共2页
Ningxia Medical Journal
