摘要
目的探讨埃索美拉唑(esomeprazole,ESO)治疗反流性食管炎(reflux esophagitis,RE)的疗效及治疗前后血清一氧化氮(NO)含量变化。方法将120例经内窥镜证实的RE患者随机分为两组,A组60例,给予埃索美拉唑40mg,每日1次;B组60例,给予奥美拉唑40mg,每日1次。两组均于每天早餐前30min用水吞服;两组疗程均为8周。分别于治疗4、8周后进行疗效和安全性评价。评价内容包括内镜表现、临床症状、24h食管pH值检测及血清含量变化。结果治疗8周时,ESO在改善RE病人临床反流症状、内镜下食管炎愈合率、24h食管pH值>4时间及血清NO含量下降方面明显优于奥美拉唑组,两组相比存在显著性差异(P<0.05)。结论埃索美拉唑是治疗RE安全、有效的药物。
Objective To explore the curative effect of esomeprazole in the treatment of reflux esophagitis （RE） and concentration of serum nitric oxide. Methods 120 patients with RE proven by gastroscope were enrolled in this . They randomly allocated to two groups,group A,and B. 60 cases in group A received therapy with esomeprazole 40mg,once a day;60 cases in group B were given omeprazole 40mg, onve a day. Before treatment and 4,8 weeks after treatment, the clinical symptoms and sisns were assessed,agastroseope was used to examine the healing state,24-hours pH-metry and concentration of serum nitric oxide. Results After 8 weeks treatment,the clinical symptoms cores were lower than that in control,the healing state under agastroscope and the time of 24-hours pH-metry 〉 4 were higher in comparison with that of controls, and the concentration of serum ni- tric oxide was significantly lower in comparison with that of controls （ P 〈 0.05 ） ; There were statistically significant differences beteen two groups. Conclusion Compared with omeprazole,in the treatment of reflux esophagitis esomeprazol is safe and effective.
出处
《临床消化病杂志》
2010年第3期166-169,共4页
Chinese Journal of Clinical Gastroenterology
