摘要
目的分析近年来糖尿病的研究进展,提高对糖尿病的认识。方法检索国内外近年来重要的糖尿病研究文献,分析这些研究成果对糖尿病防治的影响。结果多项多中心临床研究的循证医学证据显示糖尿病强化血糖控制的基本原则是:高血糖的控制越早越好;应进行个体化降糖策略;控制高血糖以外的心血管危险因素等。2型糖尿病的新药研究进展迅速。胰升血糖素样肽-1(GLP-1)类似物和DPP-4抑制剂两类药物有多方面降糖作用,具有良好的应用前景。明显肥胖型糖尿病患者手术治疗后血糖可以得到显著改善。动态血糖监测(CGM)技术已成为传统血糖监测方法的有效补充,可以全天观察血糖信息,用于指导治疗。强化生活方式干预不仅能预防糖尿病,而且对糖尿病相关的大血管和微血管并发症的发生风险有长期影响。早期强化使用胰岛素治疗能使首次确诊的2型糖尿病患者β细胞功能更好地恢复并得到维持,获得更好的疗效。结论近年糖尿病的研究结果已经对糖尿病的防治策略产生重大影响,军队"十二五"期间医学科研优先发展的领域应包括2型糖尿病的防治研究。
Objective To analyze the progress of diabetes research in recent years and to raise the understanding of the knowledge of diabetes.Methods Literature concerning diabetes published domestically and abroad in recent years were retrieved.The significance of advances gained in prevention and treatment of diabetes was analyzed.Results Evidence-based medicine data from a large number of multicenter clinical trials showed that general principles of intensive blood glucose control are as follows：controlling plasma glucose as early as possible,individualized strategy,and controlling other cardiovascular risks in addition to plasma glucose control.New drugs for treating type 2 diabetes were developed rapidly.Glycogon-like peptide-1 analogue and DPP-4 inhibitor have multiple effects of lowering plasma glucose and have good prospects in clinical application.Some studies indicated that gastric surgical procedure could significantly reduce hyperglycemia in excessively obese subjects with diabetes.CGM technique has become one effective method for monitoring the plasma glucose dynamically,which is helpful in controlling blood glucose.Intensive lifestyle intervention could not only prevent diabetes but also had some prolonged effects on macro-and microvascular complications of diabetes.Early intensive insulin treatment could protect the B cell function in newly diagnosed type 2 diabetes and maintain good control of blood glucose in long term.Conclusions The recent studies on diabetes have thrown important influences onto diabetes prevention and treatment.The priorities in the study in the armed forces in next 5 years may include prevention and treatment of type 2 diabetes.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2010年第7期777-780,共4页
Medical Journal of Chinese People's Liberation Army
关键词
糖尿病
高血糖
循证医学
患病率
diabetes mellitus
hyperglycemia
evidence-based medicine
prevalence
