摘要
目的：探讨增强型体外反搏对冠心病患者血清一氧化氮（ＮＯ）和丙二醛（ＭＤＡ）的影响。方法：采用硝酸盐还原酶法测定６９例冠心患者（反搏组３１例，药物组３８例）和３５名正常人血清中ＮＯ２－和ＮＯ３－的含量，以反映ＮＯ的浓度，同时检测血清中ＭＤＡ的含量，观察冠心病患者增强型体外反搏过程中及反搏后血清ＮＯ和ＭＤＡ的动态变化。结果：治疗前，反搏组和药物组冠心病患者血清ＮＯ含量（３８８８±１７０３）μｍｏｌ／Ｌ，（４０７８±７３８）μｍｏｌ／Ｌ明显低于正常人水平（７０８６±７６１）μｍｏｌ／Ｌ，Ｐ＜００５。经过３个疗程的增强型体外反搏治疗，患者血中ＮＯ含量明显增高（１０５４７±２５５８）μｍｏｌ／Ｌ，Ｐ＜００５，对照组经过６周药物治疗，血中ＮＯ也有一定程度的增高（４８５２±１００４）μｍｏｌ／Ｌ，但仍低于正常水平。与此相反，治疗前反搏组和药物组冠心病患者血清ＭＤＡ含量（５７４±０５３）ｎｍｏｌ／Ｌ，（５７１±０５９）ｎｍｏｌ／Ｌ明显高于正常人水平（３８７±０６５）ｎｍｏｌ／Ｌ，Ｐ＜００５。经过３个疗程的增强型体外反搏治疗，患者血中ＭＤＡ含量明显降低（４０４±０６５）ｎｍｏｌ／Ｌ，?
AIM:To investigate the effect of enhanced external counterpulsation (EECP) on serum nitric oxide (NO) and malondialdehyde (MDA) in patients with coronary heart disease METHODS:The serum NO and MDA levels of 69 cases of coronary heart disease and 35 controls were tested Patients were divided into EECP group (31 cases) and medication group (38 cases) The serum concentrations of NO and MDA were determined before, during and after treatment RESULTS: The serum NO levels in patients of EECP group and medication group were much lower than that in controls (38 88±17 03) μmol/L and (40 78±7 38) μmol/L vs (70 86±7 61) μmol/L, P <0 05 In the EECP group, the serum levels of NO increased remarkably after 1 hour or 1～3 courses EECP treatment (105 47±25 58) μmol/L, P <0 001 However the concentrations of NO in medication group increased slightly after 6 weeks treatment (48 52±10 04) μmol/L, P <0 05 On the contrary, the serum MDA levels in patients of EECP group and medication group were much higher than that in controls (5 74±0 53) nmol/L and (5 71±0 59) nmol/L vs (3 87±0 65) nmol/L, P <0 05 In the EECP group, the serum levels of MDA decreased extraordinarily after 1 hour or 1～3 courses EECP treatment (4 04±0 65) nmol/L, P <0 01. But there was no significant changes of MDA in medication group (5 60±0 55)nmol/L, P >0 05 CONCLUSION:EECP treatment improved the release of NO and reduced the production of MDA. The results may be useful in further study of EECP mechanism.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第1期14-16,共3页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
广东省卫生厅科研基金
