摘要
目的:应用事件相关脑电位(event related potential,ERP)技术探讨完全睡眠剥夺(totalsleep deprivation,TSD)对大脑执行功能的影响。方法:采用被试内两因素重复测量设计。14名健康男性硕士参加2次试验,第1次作为对照,正常睡眠;第2次接受36h睡眠剥夺。在每次试验中被试共进行5次Go/Nogo测验,同时记录事件相关脑电位N2、P3的波幅和潜伏期及行为学数据。结果:在测量时间水平上,Fz电极Nogo-N2的波幅与基线值相比,12h后减小[(-5.21±2.62)μV vs.(-6.66±3.19)μV]。Fz电极Nogo-P3的波幅和潜伏期与基线值相比,在24h后波幅下降,潜伏期延长[(8.51±7.34)μV vs.(11.80±6.70)μV;(376.36±38.68)ms vs.(364.10±39.97)ms]。在睡眠与否水平上,睡眠剥夺时Fz电极Nogo-N2、Nogo-P3的波幅低于正常睡眠值[(-4.91±3.27)μV vs.(-6.06±2.96)μV;(8.43±6.65)μV vs.(9.97±6.36)μV],Cz电极Nogo-P3的潜伏期长于正常睡眠值[(375.40±39.55)msvs.(364.96±39.17)ms]。结论:随着睡眠剥夺时间的延长,N2、P3呈现波幅逐渐减小潜伏期逐渐延长的趋势,提示睡眠剥夺可能损害大脑的执行功能。
Objective： To explore the effect of total sleep deprivation （TSD） on executive function using event related potential （ ERP ） technology. Methods： Fourteen healthy male college students participated in two trials. In the first trial they had a normal sleep and the results were taken as control. In the second trail they experienced 36 hours of sleep deprivation. In each trial the subjects were tested by five Go/Nogo tasks before Nogo-N2, Nogo- P3 amplitude and latency of ERP, and behavioral data were recorded. Results： As time points were concerned, the amplitude of Nogo-N2 on Fz electrode decreased after 12 h when compared to the baseline [ （ - 5.21 ± 2. 62 ） μV vs. { - 6. 66± 3. 19 ） μV]. The amplitude and latency of Nogo-P3 on Fz electrode changed after 24h. The amplitude decreased while the latency was extended when compared to the baseline [ （ 8.51 ± 7.34 ）μV vs. （ 11.80 ± 6.70） μV; （376.36±38.68） msvs. （364.10± 39.97） ms] .interms of sleep, the subjects experienced sleep deprivation had lower amplitude of Nogo-N2 and Nogo-P3 than their normal sleep situation [ （ -4. 91 ±3. 27 ） μV vs. （-6.06±2.96）μV; （8.43±6.65）μV vs. （9.97±6.36）μV] .The latency of Nogo-P3 on Cz electrode was longer than the normal value [ （375.40 ±39.55） ms vs. （364.96 ±39. 17） ms] . Conclusion： With the prolonging of sleep deprivation, the amplitudes of Nogo-N2 and Nogo-P3 tend to decrease while the latencies are extended gradually. This indicates that the executive function may be impaired after 36 hours of total sleep deprivation.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2010年第7期541-545,I0001,共6页
Chinese Mental Health Journal
基金
军队"十一五"医药卫生科研基金(06Z066)
关键词
睡眠剥夺
执行功能
N2
P3
事件相关脑电位
自身对照研究
total sleep deprivation （TSD）, N2, P3, executive function, event related potential （ERP）, self-control study
