摘要
目的有关创伤与免疫的研究始于1970年,经历了现象描述的起始阶段,创伤免疫抑制及其机制的初级阶段,创伤后免疫功能紊乱的发展阶段,以及当前的创伤后免疫调理防治脓毒症的第四阶段。对于脓毒症的免疫调理策略应把握"堵"、"疏"兼顾的原则,既对脓毒反应的启动采取拮抗的防治措施,又着眼于提高机体抵抗力,特别是提高机体的应激反应能力;早期以"堵"为主,晚期以"疏"为主,同时注重动态调整机体最佳的应激反应状态。
There were four stages in the establishment,development and evolvement of the research history about trauma and immunity which began in 1970s,namely the initiatory stage describing phenomena,primary stage focusing at mechanism of immunosuppression,developing stage proposing immune dysfunction notion,and the fourth stage,the immunomodulating stage.Three key points should be paid more attention during the immunomodulation of sepsis.Firstly,block and release,we should not only block the initiators or triggers of sepsis,but also release and promote the metabolization of inflammatory mediators and dangerous signal produced during sepsis,especially to improve the ability in stress response.Secondly,predominantly block at early stage and release at late stage.Thirdly,adjust the immune status dynamically for guidance and regulation of sepsis treatment.
出处
《创伤外科杂志》
2010年第4期289-292,共4页
Journal of Traumatic Surgery
关键词
脓毒症
创伤
免疫
sepsis
trauma
immunology
