摘要
单用促性腺激素（gonadotropin，Gn）控制性超排卵（COS）可引起多个卵泡发育，雌激素水平上升且较自然周期高，20％～25％患者在卵泡形态和功能上尚未达到完全成熟能力的阶段即可诱发过早的高水平黄体生成素（LH）释放，进而导致卵泡过早黄素化、卵子质量受损、受精率和妊娠率下降、流产率增高、甚至取消周期。1984年，Porter等首先应用促性腺激素释放激素激动剂（GnRH—a）在COS周期进行降调节，取得较好的效果。
In controlled ovarian stimulation （COS）, GnRH-a down regulation is able to prevent endogenous LH surge at the intermediate late stages, to avoid premature luteinization of follicles, to improve oocyte quality and the success rate of IVF-ET. However, for a high ovarian responder or low responder, the down regulation protocol is not the best option to achieve IVF-ET success. To reduce the detrimental effect of the high dose gonadotropin in the down-regulation protocol, mild stimulation protocol might become the mainstream of COS treatment.
出处
《生殖医学杂志》
CAS
2010年第3期179-181,共3页
Journal of Reproductive Medicine
