体外受精中的黄体期降调节长方案控制超排卵被引量：2

Controlled ovarian superovulation with the luteal initiation of long protocol

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摘要控制性超排卵（COH）应用于体外受精（IVF）已有30余年，人们一直致力于探讨合理的、个体化的COH方案，以获得足够的高质量卵子，从而保障获得理想的妊娠率。黄体期降调节长方案已经在临床广泛应用。我中心将该方案主要应用于年龄≤38岁，且排卵功能正常的妇女。本文总结使用该方案患者的临床资料，探讨其应用的有效性与安全性。 Objective：To investigate the efficiency and safety phase initiation of long protocol in IVF/ICSI cycles. of controlled ovarian superovulation with the luteal Methods： A retrospective analysis of clinical data. Results： A total of 1666 IVF/ICSI cycles with the luteal phase initiation of long protocol downregulation from Jan. 2007 to Sep. 2009 were analyzed retrospectively. The clinical pregnancy rate per transfer was 70. 31% （1118/1590）. The live birth rate per transfer was 59.8%（660/l104）from Jan. 2007 to Dec. 2008. The cumulative pregnancy rate per aspiration was 76.8% in 1127 finished aspiration cycles from Jan. 2007 to Dec. 2008. 1659 aspiration cycles from Jan. 2007 to Sep. 2009 were divided into five groups according to the number of oocytes retrieved： ≤5, 6 - 10, 11- 15, 16 -20 and ） 20. The implantation rate was 33.5%, 46.9%, 50.7%, 49.9% and 55.4% respectively, and the incidence of OHSS was 3.82%, 5.47%, 8.82%, 18.54% and 14.81%, respectively, for these five groups. The distribution of singleton, twin and triplet pregnancy after IVF/ICSI was 58. 5%, 39. 8% and 1. 7%, respectively. Conclusion： The luteal phase initiation of long protocol is efficient, but its safety should be improved.

作者孙海翔

机构地区南京大学医学院附属鼓楼医院生殖医学中心

出处《生殖医学杂志》 CAS 2010年第3期191-193,共3页 Journal of Reproductive Medicine

关键词黄体期降调节长方案有效性安全性 Luteal initiation of long protocol Efficiency Safety

分类号 R [医药卫生]

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1Nyboe Andersen A,Goossens V,Bhattacharya S,et al.Assisted reproductive technology and intrauterine inseminations in Europe,2005:results generated from European registers by ESHRE:ESHRE[J].Hum Reprod,2009,24(6):1267-1287.
2Thurin A,Hausken J,Hillensj T,et al.Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization[J].N Engl J Med,2004,351(23):2392-3402.
3Thurin-Kjellberg A,Olivius C,Bergh C.et al.Cumulative live-birth rates in a trial of single-embryo or double-embryo transfer[J].N Engl J Med,2009,361(18):1812-1813.
4Patrizio P,Sakkas D.From oocyte to baby:a clinical evaluation of the biological efficiency of in vitro fertilization[J].Fertil Steril,2009,91(4):1061-1066.
5Meniru GI,Craft IL.Utilization of retrieved oocytes as an index of the efficiency of superovulation strategies for in-vitro fertilization treatment[J].Hum Reprod,1997,12(10):2129-2132.