摘要
目的研究尖锐湿疣(CA)病人阴毛毛囊和皮损处人乳头状瘤病毒(HPV)阳性率及亚型分布,了解HPV亚型与临床发病的关系。方法采用PCR方法对尖锐湿疣病人皮损和阴毛毛囊中的HPV进行亚型检测。结果尖锐湿疣病人皮损处HPV阳性率为96.15%(100/104),其中75例为HPV6亚型,32例为HPV11亚型,两者混合感染11例,4例为其他亚型。尖锐湿疣病人阴毛毛囊中HPV阳性率为32.56%,其中19例为HPV6亚型,9例为HPV11亚型,两者混合感染2例,2例为其他亚型。尖锐湿疣病人皮损组织中HPV阳性率明显高于阴毛毛囊HPV阳性率(2χ=82.15,P<0.01)。尖锐湿疣病人阴毛毛囊中的HPV亚型分布与皮损中HPV亚型分布一致,两者无显著性差异(P>0.05)。结论引起男性尖锐湿疣的HPV亚型以HPV6、11亚型为主。
Objective To investigate the distribution of human papillomavirus （HPV） subtypes in patients with condylo- ma acuminata （CA） its relation with clinical morbidity. Methods Specimens from folliculus pill of pubic hairs and skin lesions of patients with CA were detected and checked for HPV subtypes. Results The positive HPV in impaired skin was 96.15%（100/ 104）, in which, 75 was classified as subtype HPV6, and 32 as HPVll, combined infection of the above two subtypes was 11 ca ses, and four eases were other subtypes. The specimens taken from folliculus pill showed that HPV was positive in 32. 56%, in which, 19 were subtype HPV6, nine were HPV11, combined infection of HPV6 and HPVll found in two, and the other two cases were other subtypes. The positive rate of HPV in damaged skin was remarkably higher than that of the folliculus pill （χ2=82.15, P〈0.01）. Differences of the distribution of the subtypes between the two groups were not significant （P〉0.05）. Conclusion The main cause of HPV subtype that responsible for CA in men is HPV6 and HPV 11.
出处
《青岛大学医学院学报》
CAS
2010年第4期360-361,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
尖锐湿疣
乳头状瘤病毒
人
皮损
condylomata aeuminata
papillomavirus, human
skin lesion
