摘要
目的探讨短暂性脑缺血发作(TIA)患者认知功能与蒙特利尔认知评估量表(MoCA)评分、事件相关电位(P300)及血清神经元特异性烯醇化酶(NSE)水平的关系。方法 61例TIA患者,在其最近发作3d内进行MoCA、P300及血清NSE检测,并与40名健康对照者(正常对照组)进行比较。结果 TIA组的MoCA评分[(16.59±5.74)分]、P300潜伏期[(355.50±38.52)ms]及P300波幅[(3.11±1.65)μV]、血清NSE水平[(18.95±8.78)ng/ml]与正常对照组[(27.58±1.36)分、(310.66±30.12)ms、(5.22±2.72)μV、(11.34±4.67)ng/ml]比较差异有统计学意义(均P<0.01)。TIA≤5次患者MoCA评分、P300潜伏期及血清NSE水平与TIA>5次患者比较差异有统计学意义(均P<0.01)。相关性分析显示,TIA患者MoCA评分与P300潜伏期、血清NSE水平负相关(r=-0.444,r=-0.447;均P<0.01),P300潜伏期与血清NSE水平正相关(r=0.425,P<0.01)。TIA组中,MoCA异常率(86.9%,53例)显著高于P300潜伏期的异常率(37.7%,23例)(P<0.01)。结论 MoCA、P300检测能反映TIA患者的认知功能损害,并与血清NSE水平相关。MoCA评分对TIA认知功能损害的识别优于P300。
Objective To investigate the relationship between the congnitive function and score of Montreal cognitive assessment（MoCA） scale,event-related potential （P300） and serum neuron specific enolase level in patients with transient ischemic attack （TIA）.Methods The test of MoCA and P300 were performed,and serum NSE level was detected in 61 TIA patients （TIA group） within 3 days of TIA and 40 healthy controls （normal control group）.Results The score of MoCA （16.59±5.74 ）,P300 latency period[（355.50±38.52）ms],P300 amplitude[（3.11±1.65） μV ]and serum NSE level[（18.95±8.78） ng/ml] in TIA group were significantly different compared with those in normal control group[（27.58±1.36）,（310.66±30.12）ms,（5.22±2.72）μV,（11.34±4.67）ng/ml] （all P0.01）. The score of MoCA,P300 latency period and serum NSE level in TIA patients with attack≤5 times were significantly different compared with those in patients with attack5 times （all P0.01）. By the correlation analysis,in the TIA group,the score of MoCA was negative correlated with the P300 latency period and serum NSE level（r=-0.444,r=-0.447; all P0.01）. While,the P300 latency period was positive correlation with serum NSE level （r=0.425,P0.01）. The abnormal rate of MoCA （86.9%,53 cases） was obviously higher than that of P300 latency period （37.7%,23 cases） in the TIA group（P0.01）.Conclusions Cognitive dysfunction in TIA patients can be detected by the MoCA and P300 evaluation,which are correlated to the serum NSE level. It is the better way to screening cognitive impairment in TIA patients by MoCA scale than P300.
出处
《临床神经病学杂志》
CAS
北大核心
2010年第3期168-170,共3页
Journal of Clinical Neurology
基金
江苏省中医药管理局项目(LB09090)
